Cytotoxicity and Apoptosis Induction of Bovine Alpha-lactalbumin-oleic Acid Complex in Human Breast Cancer Cells
文献类型： 外文期刊
作者： Zhong, Saiyi 1 ; Liu, Shouchun 2 ; Chen, Suhua 1 ; Liu, Hai 3 ; Zhou, Siyi 1 ; Qin, Xiaoming 1 ; Wang, Weimin 1 ;
作者机构： 1.Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Guangdong, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Beijing 100097, Peoples R China
3.Guangdong Ocean Univ, Dept Expt Teaching, Modern Biochem Ctr, Zhanjiang 524088, Guangdong, Peoples R China
关键词： bovine alpha-lactalbumin-oleic acid;cytotoxicity;apoptosis;human breast cancer cells
期刊名称：FOOD SCIENCE AND TECHNOLOGY RESEARCH （ 影响因子：0.668； 五年影响因子：0.895 ）
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收录情况： SCI
摘要： Breast cancer is the mostly commonly diagnosed cancer in women worldwide. Using food-based approach to breast cancer chemoprevention has attracted a great deal of attention in recent years. In the present study, a-lactalbumin was purified from fresh bovine milk and the complex with oleic acid (BLA-OA Complex) was prepared by chromatographic method. The cytotoxic and apoptotic activities of BLA-OA complex on human ERpositive MCF-7 and ER-negative MDA-MB-231 breast cancer cells was investigated by morphological observation, MTS assay, LDH release, DAPI staining, DNA ladder assay and cell cycle analysis. The results showed that BLA-OA complex inhibits cells growth and induces apoptosis in both human ER-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cell lines. The findings of this study are positive for cow milk industry and human breast cancer chemoprevention.
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