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Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells

文献类型： 外文期刊

作者： Li, Pu-Wang 1 ; Wang, Guang 1 ; Yang, Zi-Ming 1 ; Duan, Wei 2 ; Peng, Zheng 1 ; Kong, Ling-Xue 2 ; Wang, Qing-Huang 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang, Peoples R China

2.Deakin Univ, Inst Frontier Mat, Geelong, Vic 3217, Australia

3.Natl Ctr Important Trop Crops Engn & Technol Res, Haikou, Peoples R China

关键词： Chitosan;cytotoxicity;drug delivery system;nanoparticles;vanillin

期刊名称：DRUG DELIVERY （ 影响因子：6.419； 五年影响因子：6.169 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Chitosan as a natural polysaccharide derived from chitin of arthropods like shrimp and crab, attracts much interest due to its inherent properties, especially for application in biomedical materials. Presently, biodegradable and biocompatible chitosan nanoparticles are attractive for drug delivery. However, some physicochemical characteristics of chitosan nanoparticles still need to be further improved in practice. In this work, chitosan nanoparticles were produced by crosslinking chitosan with 3-methoxy-4-hydroxybenzaldehyde (vanillin) through a Schiff reaction. Chitosan nanoparticles were 200-250nm in diameter with smooth surface and were negatively charged with a zeta potential of-17.4mV in neutral solution. Efficient drug loading and drug encapsulation were achieved using 5-fluorouracil as a model of hydrophilic drug. Drug release from the nanoparticles was constant and controllable. The in vitro cytotoxicity against HT-29 cells and cellular uptake of the chitosan nanoparticles were evaluated by methyl thiazolyl tetrazolium method, confocal laser scanning microscope and flow cytometer, respectively. The results indicate that the chitosan nanoparticles crosslinked with vanillin are a promising vehicle for the delivery of anticancer drugs.

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[1]Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery. Wang, Yichao,Li, Puwang,Kong, Lingxue,Li, Puwang. 2013

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[19]Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells. Li, Puwang,Wang, Yichao,Kong, Ling Xue,Li, Puwang,Peng, Zheng,Zeng, Fanbo,Chen, Lijue.

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