Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea
文献类型： 外文期刊
作者： Pan, Le 1 ; Li, Xiuzhuang 2 ; Gong, Chengwen 4 ; Jin, Hui 2 ; Qin, Bo 2 ;
作者机构： 1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources CAS, Lanzhou 730000, Peoples R China
3.Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China
4.Gansu Acad Agr Sci, Inst Chinese Med Herbs, Lanzhou 730070, Peoples R China
关键词： N-substituted phthalimides;Synthesis;IC50 values;Antifungal activity
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）
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收录情况： SCI
摘要： As organosulfur and organophosphorus agents, phaltane and phosmet are facing great challenges for the environmental contamination, mammalian toxicity and increasing resistance with long term use. It is efficient and meaningful to develop phthalimide-based alternatives with non-sulfur and non phosphorus groups. A series of N-substituted phthalimides were synthesized and their antifungal activity against two disastrous phytopathogenic fungi, Alternaria solani and Botrytis cinerea was evaluated in vitro. Most of them showed significant antifungal activity against both of fungi, or either of them selectively. N-vinylphthalimide (4) and 844-(phthalimide-2-yl) butyloxy] quinoline (13) were identified as the most promising candidates against B. cinerea and A. solani with the IC50 values of 7.92 mu g/mL and 10.85 mu g/mL respectively. The brief structure-activity relationships have revealed that vinyl, quinolyl, bromide alkyl and benzyl substitutions were appropriate substituents and coupling functional moieties indirectly with optimum alkyl chain was efficient to prepare phthalimides related fungicides. (C) 2016 Elsevier Ltd. All rights reserved.
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