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Combined cytotoxic effects of pesticide mixtures present in the Chinese diet on human hepatocarcinoma cell line

文献类型： 外文期刊

作者： Ma, Mengmeng 1 ; Chen, Chen 1 ; Yang, Guiling 1 ; Li, Yun 1 ; Chen, Zhijun 1 ; Qian, Yongzhong 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety, Minist Agr, Beijing 100081, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Minist Agr, Key Lab Pesticide Residue Detect, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Pesticide mixtures;Cytotoxicity;HepG2;Combined effects;Cell apoptosis

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

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收录情况： SCI

摘要： Consumers might be simultaneously exposed to several pesticide residues contained in their food. Based on the results of previous studies, 20 pesticides were selected due to their high exposure levels to which the Chinese population is likely exposed through the diet. The purpose of this study was to measure the cytotoxicity of these pesticides in HepG2 cells in vitro, as an alternative approach to assess the toxicity of chemicals. Then, the pesticides and some of the mixtures with comparatively high cell-proliferating inhibitory activities were selected to test the cellular ROS level and apoptosis-related protein Caspase-3/7 content in HepG2 cells. The combined effects of these pesticide mixtures with the prediction was based on a combination index (CI)-isobologram equation and the pesticide combinations exhibited various types of interactions (synergism, antagonism, and additivity). Two individuals, one binary combinations, and three uniform design (UD) mixtures of the pesticides were found to have significant cytotoxic effects, along with significant time- and dose-dependent induction of caspase-3/7 activity in vitro, indicating that cytotoxicity caused by these pesticides might be attributed to the pro-oxidative and apoptosis induced potential. (C) 2016 Published by Elsevier Ltd.

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