Wortmannines A-C, three novel wortmannin derivatives with an unusual five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4
文献类型： 外文期刊
作者： Fu, Guang-Chao 1 ; Yang, Zhong-Duo 1 ; Zhou, Shuang-Yan 3 ; Li, Xin-Ming 4 ; Yu, Hai-Tao 6 ; Yao, Xiao-Jun 3 ; Fang, J 1 ;
作者机构： 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China
2.Lanzhou Univ Technol, Sch Life Sci & Engn, Prov Educ Key Lab Screening Evaluat & Adv Proc Tr, Lanzhou 730050, Peoples R China
3.Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China
4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
5.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
6.Gansu Acad Agr Sci, Inst Plant Protect, Lanzhou 730070, Peoples R China
关键词： Talaromyces;Wortmannine;Structure elucidation;Cytotoxic activity
期刊名称：TETRAHEDRON LETTERS （ 影响因子：2.415； 五年影响因子：2.036 ）
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收录情况： SCI
摘要： Wortmannine A (1), a dinor-carbon wortmannin derivative with an unusual five-membered B ring, together with wortmannine B (2), a wortmannin derivative bearing an unusual five-membered B ring and lactam E-ring, and wortmannine C (3), a wortmannin derivative bearing an unusual five-membered B ring and a lactone E-ring, as well as wortmannine D (4), a 4-methyl substituted androstadiene-17-one, were purified from the zeistic culture of Talaromyces wortmannii LGT-4. The structures of 1-4 were elucidated by comprehensive NMR spectroscopy, Mosher's method and single-crystal X-ray crystallography. Additional known compounds (5-8) were also isolated. The isolates were tested for cytotoxic activities and compound 5, entonaemin A, showed anti-HL60 activity with IC(50)s of 15.0 mu M (24 h) and 12.4 mu M (48 h). (C) 2016 Elsevier Ltd. All rights reserved.
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