您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Chromatography column comparison and rapid pretreatment for the simultaneous analysis of amantadine, rimantadine, acyclovir, ribavirin, and moroxydine in chicken muscle by ultra high performance liquid chromatography and tandem mass spectrometry

文献类型： 外文期刊

作者： Zhang, Qiaoyan 1 ; Xiao, Chaogeng 2 ; Wang, Wei 1 ; Qian, Mingrong 1 ; Xu, Jie 1 ; Yang, Hua 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou, Zhejiang, Peoples R China

关键词： Amide columns;Antivirals;Hydrophilic interactions;QuEChERS

期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In this work, a chromatography column comparison and rapid pretreatment development were carried out. A multi-class method was built based on the quick, easy, cheap, effective, rugged, and safe pretreatment method with hydrophilic interaction ultra high performance liquid chromatography and tandem mass spectrometry for the high-throughput analysis of five antivirals in chickenmuscle. TheHSS T3 column, BEH HILIC column and BEH Amide column were studied, and their chemical functionalities and chromatographic separation effectiveness were compared. The BEH Amide column was selected to perform the mass spectrometry analysis under the hydrophilic interaction chromatography mode. First, a different strategy without adding MgSO4 and NaCl into the muscle samples was considered. Then, different concentrations of formic acid, acetic acid, and ammonia in acetonitrile were compared for better extraction efficiency. Nine sorbents (C-18, PSA, NH2, Florisil, Alumina-B, Alumina-N, PestiCarb, NANO, and NANO-NH2) were studied. The optimized procedure consisted of the use of 10% acetic acid in acetonitrile for the extraction solvent and NANO-NH2 for clean-up. NANO-NH2 had not been applied in other matrix and pollutants so far. The developed method provided favorable trueness, precision, and acceptable matrix effect. Meanwhile, the method was sensitive, the limits of detection of amantadine, rimantadine, acyclovir, ribavirin, and moroxydine achieved were 0.56, 0.50, 0.30, 2.22, and 0.51 mu g/kg, respectively, and were successfully applied for the routine detection of antivirals in the chicken samples.

  • 相关文献

[1]Simultaneous determination of chlorpyrifos and 3,5,6-trichloro-2-pyridinol in duck muscle by modified QuEChERS coupled to gas chromatography tandem mass spectrometry (GC-MS/MS). Li, Rui,Ji, Xiaofeng,Qian, Mingrong,Zhou, Yu,Wang, Qiang,Li, Rui,Ji, Xiaofeng,Qian, Mingrong,Zhou, Yu,Wang, Qiang,Li, Rui,Ji, Xiaofeng,Qian, Mingrong,Zhou, Yu,Wang, Qiang,Li, Rui,Ji, Xiaofeng,Qian, Mingrong,Zhou, Yu,Wang, Qiang,He, Liang,Zhou, Ting.

[2]Simultaneous determination of carbamate insecticides and mycotoxins in cereals by reversed phase liquid chromatography tandem mass spectrometry using a quick, easy, cheap, effective, rugged and safe extraction procedure. Zhang, Jin-Ming,Lu, Yao-Bin,Wu, Yin-Liang.

[3]QuEChERS-高效液相色谱法测定杨梅果实中苯醚甲环唑和乙基多杀菌素的农药多残留. 王天玉,姚周麟,平新亮,张伟清,冯先橘,林媚. 2017

[4]超高效液相色谱-串联质谱法测定浙贝母中6种农药残留. 俞建忠,苍涛,戴芬,赵学平. 2018

[5]QuEchERS-超高效液相色谱-串联质谱法同时测定草莓中85种农药残留. 王姗姗,王莉,程媛媛,范艳,王菲迪,吴声敢. 2018

[6]QuEChERS净化-高效液相色谱-串联质谱法测定蜂蜜中农药及抗生素的含量. 苗琼晨,聂晶,吴慧珍,钱鸣蓉,孙彩霞,李祖光. 2017

[7]UPLC–MS/MS同时测定山楂干制品中的8种真菌毒素. 吉小凤,杨华,汪建妹,倪晓蕾,张永华,钱鸣蓉. 2019

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台