文献类型： 外文期刊

作者： Liu, Chunsheng ¹ ; Zhang, Zihan ² ; Li, Boqun ² ; Huang, Kai ¹ ; Zhang, Yongkang ² ; Li, Meng ³ ; Letcher, Robert J. ⁴ ;

作者机构： 1.China Univ Geosci, Sch Environm Studies, Wuhan 430074, Peoples R China

2.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

3.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

4.Carleton Univ, Dept Chem & Biol, Ottawa, ON K1S 5B6, Canada

关键词： the Yangtze river; organophosphate esters; silver carp; lipid metabolic disorder

期刊名称：ENVIRONMENTAL SCIENCE & TECHNOLOGY （ 影响因子：11.4； 五年影响因子：12.0 ）

ISSN： 0013-936X

年卷期： 2024 年 58 卷 11 期

页码：

收录情况： SCI

摘要： The Yangtze River fishery resources have declined strongly over the past few decades. One suspected reason for the decline in fishery productivity, including silver carp (Hypophthalmichthys molitrix), has been linked to organophosphate esters (OPEs) contaminant exposure. In this study, the adverse effect of OPEs on lipid metabolism in silver carp captured from the Yangtze River was examined, and our results indicated that muscle concentrations of the OPEs were positively associated with serum cholesterol and total lipid levels. In vivo laboratory results revealed that exposure to environmental concentrations of OPEs significantly increased the concentrations of triglyceride, cholesterol, and total lipid levels. Lipidome analysis further confirmed the lipid metabolism dysfunction induced by OPEs, and glycerophospholipids and sphingolipids were the most affected lipids. Hepatic transcriptomic analysis found that OPEs caused significant alterations in the transcription of genes involved in lipid metabolism. Pathways associated with lipid homeostasis, including the peroxisome proliferator-activated receptor (PPAR) signal pathway, cholesterol metabolism, fatty acid biosynthesis, and steroid biosynthesis, were significantly changed. Furthermore, the affinities of OPEs were different, but the 11 OPEs tested could bind with PPAR gamma, suggesting that OPEs could disrupt lipid metabolism by interacting with PPAR gamma. Overall, this study highlighted the harmful effects of OPEs on wild fish and provided mechanistic insights into OPE-induced metabolic disorders.