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Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omics and DESI-MSI

文献类型： 外文期刊

作者： Xia, Jie 1 ; Lou, Ganggui 1 ; Zhang, Lan 1 ; Huang, Yanbo 2 ; Yang, Jian 3 ; Guo, Juan 3 ; Qi, Zhechen 1 ; Li, Zhenhao 4 ; Zhang, Guoliang 4 ; Xu, Shengchun 5 ; Song, Xijiao 5 ; Zhang, Xiaodan 1 ; Wei, Yukun 6 ; Liang, Zongsuo 1 ; Yang, Dongfeng 1 ;

作者机构： 1.Zhejiang Sci Tech Univ, Coll Life Sci & Med, Key Lab Plant Secondary Metab & Regulat Zhejiang P, Hangzhou 310000, Peoples R China

2.Shanghai Chenshan Bot Garden, Eastern China Conservat Ctr Wild Endangered Plant, Shanghai 200000, Peoples R China

3.China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Breeding Base Dao Di Herbs, Beijing 100000, Peoples R China

4.Zhejiang Shouxiangu Bot Drug Inst Co Ltd, Hangzhou 310000, Peoples R China

5.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310000, Peoples R China

6.Shanghai Bot Garden, Shanghai, Peoples R China

期刊名称：HORTICULTURE RESEARCH （ 影响因子：8.7； 五年影响因子：9.0 ）

ISSN： 2662-6810

年卷期： 2023 年 10 卷 7 期

页码：

收录情况： SCI

摘要： Salvia miltiorrhiza and S. grandifolia are rich in diterpenoids and have therapeutic effects on cardiovascular diseases. In this study, the spatial distribution of diterpenoids in both species was analyzed by a combination of metabolomics and mass spectrometry imaging techniques. The results indicated that diterpenoids in S. miltiorrhiza were mainly abietane-type norditerpenoid quinones with a furan or dihydrofuran D-ring and were mainly distributed in the periderm of the roots, e.g. cryptotanshinone and tanshinone IIA. The compounds in S. grandifolia were mainly phenolic abietane-type tricyclic diterpenoids with six- or seven-membered C-rings, and were widely distributed in the periderm, phloem, and xylem of the roots, e.g. 11-hydroxy-sugiol, 11,20-dihydroxy-sugiol, and 11,20-dihydroxy-ferruginol. In addition, the leaves of S. grandifolia were rich in tanshinone biosynthesis precursors, such as 11-hydroxy-sugiol, while those of S. miltiorrhiza were rich in phenolic acids. Genes in the upstream pathway of tanshinone biosynthesis were highly expressed in the root of S. grandifolia, and genes in the downstream pathway were highly expressed in the root of S. miltiorrhiza. Here, we describe the specific tissue distributions and mechanisms of diterpenoids in two Salvia species, which will facilitate further investigations of the biosynthesis of diterpenoids in plant synthetic biology.

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