UPLC-Q-TOF/MS-based metabonomics reveals mechanisms for Holothuria leucospilota polysaccharides (HLP)-regulated serum metabolic changes in diabetic rats
文献类型： 外文期刊
作者： Zhang, Xin 1 ; Zhao, Fuqiang 1 ; Ma, Tingting 1 ; Zheng, Yuanping 1 ; Cao, Jun 1 ; Li, Chuan 1 ; Zhu, Kexue 2 ;
作者机构： 1.Hainan Univ, Engn Res Ctr Utilizat Trop Polysaccharide Resource, Hainan Engn Res Ctr Aquat Resources EfficientUtili, Sch Food Sci & Engn,Minist Educ, Haikou 570228, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Prov Key Lab Genet Improvement & Qual Regu, Spice & Beverage Res Inst, Wanning 571533, Peoples R China
3.Dalian Polytech Univ, Collaborat Innovat Ctr Prov & Ministerial Coconstr, Dalian 116034, Peoples R China
4.Hainan Univ, Sch Food Sci & Engn, Haikou 570228, Hainan, Peoples R China
5.Chinese Acad Trop Agr Sci, Key Lab Proc Suitabil & Qual Control Special Trop, Wanning 571533, Peoples R China
关键词： Holothuria leucospilota; Polysaccharides; Diabetes mellitus; Metabolomics; Bile acid metabolism
期刊名称：FOOD CHEMISTRY-X （ 影响因子：6.1； 五年影响因子：6.4 ）
ISSN： 2590-1575
年卷期： 2023 年 19 卷
页码：
收录情况： SCI
摘要： This study aimed to use metabolomic methods to explore how Holothuria leucospilota polysaccharides (HLP) improved metabolism disorders in the liver of Goto-Kakizaki (GK) rats with spontaneous type 2 diabetes. The results showed that HLP effectively improved the metabolic disorder. Based on KEGG functional analysis, five key biomarkers associated with bile acid metabolism were detected and screened (P < 0.05). The results of serum total bile acid levels and liver damage in diabetic rats further showed the regulatory effects of HLP on bile acid metabolism. The results of bile acid-related gene expression in the liver showed that HLP inhibited liver farnesoid X Receptor - small heterodimer partner (FXR-SHP) signalling and increased the expression of bile acid synthesis genes (P < 0.05). Our results explored the underlying mechanisms by which HLP accelerated cholesterol consumption to anti-hypercholesterolemia and anti-diabetic by inhibiting liver FXR-SHP signaling. HLP's effect on bile acid regulation provides insights into treating T2DM.
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