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Environmental concentrations of TCEP and TDCIPP induce dysbiosis of gut microbiotal and metabolism in the honeybee (Apis mellifera L.)

文献类型： 外文期刊

作者： Cang, Tao 1 ; Gu, Weijie 2 ; Zhu, Yu-Cheng 3 ; Guo, Mingcheng 4 ; Lv, Lu 1 ; Wu, Changxing 1 ; Jin, Yuanxiang 2 ; Wang, Yanhua 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Qual & Safety Agroprod, Hangzhou 310021, Zhejiang, Peoples R China

2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310032, Zhejiang, Peoples R China

3.ARS, USDA, 141 Expt Stn Rd, Stoneville, MS 38776 USA

4.Minist Agr & Rural Affairs, Inst Control Agrochem, Beijing 100125, Peoples R China

关键词： Pollination insect; Gut microbial communities; Organophosphorus flame retardants; Metabolic disturbance

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）

ISSN： 0304-3894

年卷期： 2025 年 491 卷

页码：

收录情况： SCI

摘要： Organophosphorus flame retardants (OPFRs) have emerged as significant global pollutants, yet their harmful effects on pollinating insects remain largely unexplored. This study explored the toxicological effects of tri(2-chloroethyl) phosphate (TCEP) and tri(1,3-dichloro-2-propyl) phosphate (TDCIPP) on the gut microbiota and metabolic pathways of honeybees (Apis mellifera L.). Exposure to TCEP led to a 35 % reduction in intestinal wall thickness and significantly suppressed the expression of pyrimidine metabolism-associated enzymes, including CAD, DHODH, and ODCase (p < 0.05). In contrast, TDCIPP exposure increased the relative abundance of Snodgrassella and Lactobacillus by 40 % and 25 %, respectively, while exerting more extensive toxicity by disrupting nucleotide metabolism, oxidative stress responses, and microbial diversity. Histological assessments revealed that both chemicals compromised intestinal wall integrity and induced crypt loss in the midgut epithelium. Multi-omics analyses underscored distinct toxicity mechanisms: TCEP primarily inhibited pyrimidine biosynthesis, impairing nucleotide synthesis and DNA repair processes, whereas TDCIPP caused broader metabolic disturbances, likely attributed to its greater hydrophobicity. Notably, the enhanced prevalence of certain microbial taxa suggests potential microbial adaptations to TDCIPP-induced stress. This comparative analysis highlighted the detrimental effects of TCEP and TDCIPP on gut health and metabolism, critical factors for honeybee survival and ecological function. These findings underscored the urgent need for further investigation into the ecological hazards posed by OPFRs and provided a basis for developing mitigation strategies to address the impacts of persistent organic pollutants (POPs) on pollinators.

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