文献类型： 外文期刊

作者： Xu, Xiaoyu ¹ ; Chen, Liurong ⁵ ; Luo, Yucai ¹ ; Gao, Ruanling ¹ ; Xu, Yingting ¹ ; Yang, Jie ⁵ ; Zhou, Zhongyu ¹ ; Wei, Xiaoyi ¹ ;

作者机构： 1.Chinese Acad Sci, Key Lab South China Agr Plant Mol Anal & Genet Imp, Guangzhou 510650, Peoples R China

2.Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Peoples R China

3.Fujian Acad Agr Sci, Inst Crop Sci, Fuzhou 350013, Peoples R China

4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

5.Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangzhou 510515, Peoples R China

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）

ISSN： 0163-3864

年卷期：

页码：

收录情况： SCI

摘要： Four new cyclic diarylheptanoids, casuarinols A-C (1-3) and casuarinolide A (4), together with six known ones (5- 10), were isolated from the roots of Casuarina equisetifolia. Structures were elucidated by extensive spectroscopic analysis, theoretical conformational, and electronic circular dichroism analyses. Casuarinol C (3) is a novel cyclic diarylheptanoid-aldehyde adduct. Casuarinolide A (4) represents the first structure of a seco-cyclic diarylheptanoid. Compounds 1-9 were evaluated for their anti influenza A virus (IAV) activity against A/WSN/33 (H1N1). (-)-(M)-11-Oxo-3,12R,17-trihydroxy-9-ene-[7,0]-metacyclophane (5) displayed significant anti-IAV activity with an IC50 value of 8.64 +/- 2.49 mu M and a CC50 higher than 100 mu M.