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Cu exposure induces liver inflammation via regulating gut microbiota/LPS/ liver TLR4 signaling axis

文献类型： 外文期刊

作者： Gu, Tiantian 1 ; Kong, Minghua 4 ; Duan, Mingcai 1 ; Chen, Li 1 ; Tian, Yong 1 ; Xu, Wenwu 1 ; Zeng, Tao 1 ; Lu, Lizhi 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Livestock & Poultry Resources Poultry Eval, Hangzhou 310021, Peoples R China

4.Westlake Univ, Sch Life Sci, Hangzhou 310024, Peoples R China

5.Zhejiang Key Lab Livestock & Poultry Breeding, Hangzhou 310021, Guangdong, Peoples R China

6.Zhejiang Prov Engn Res Ctr Poultry Breeding Ind &, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Cu; Liver inflammation; Gut microbiota; Fecal microbiota transplantation; Duck

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.2； 五年影响因子：6.3 ）

ISSN： 0147-6513

年卷期： 2024 年 278 卷

页码：

收录情况： SCI

摘要： Copper (Cu) serves as an essential cofactor in all organisms, yet excessive Cu exposure is widely recognized for its role in inducing liver inflammation. However, the precise mechanism by which Cu triggers liver inflammation in ducks, particularly in relation to the interplay in gut microbiota regulation, has remained elusive. In this investigation, we sought to elucidate the impact of Cu exposure on liver inflammation through gut-liver axis in ducks. Our findings revealed that Cu exposure markedly elevated liver AST and ALT levels and induced liver inflammation through upregulating pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF-alpha) and triggering the LPS/ TLR4/NF-kappa B signaling pathway. Simultaneously, Cu exposure induced alterations in the composition of intestinal flora communities, notably increasing the relative abundance of Sphingobacterium, Campylobacter, Acinetobacter and reducing the relative abundance of Lactobacillus. Cu exposure significantly decreased the protein expression related to intestinal barrier (Occludin, Claudin-1 and ZO-1) and promoted the secretion of intestinal proinflammatory cytokines. Furthermore, correlation analysis was observed that intestinal microbiome and gut barrier induced by Cu were closely related to liver inflammation. Fecal microbiota transplantation (FMT) experiments further demonstrated the microbiota-depleted ducks transplanting fecal samples from Cu-exposed ducks disturbed the intestinal dysfunction, which lead to impaire liver function and activate the liver inflammation. Our study provided insights into the mechanism by which Cu exposure induced liver inflammation in ducks through the regulation of gut-liver axis. These results enhanced our comprehension of the potential mechanisms driving Cu-induced hepatotoxicity in avian species.

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