Aqueous extracts of Sanghuangporus vaninii induce S-phase arrest and apoptosis in human melanoma A375 cells
文献类型： 外文期刊
作者： Yu, Taihen 1 ; Zhong, Shi 2 ; Sun, Yuqing 2 ; Sun, Haiyan 3 ; Chen, Weiguo 3 ; Li, Yougui 2 ; Zhu, Jianxun 2 ; Lu, Longxi 4 ;
作者机构： 1.Hangzhou Med Coll, Affiliated Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Radiol, Hangzhou 310014, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, 298 Desheng Rd, Hangzhou 310021, Zhejiang, Peoples R China
3.Haining Agr & Rural Bur, Haining Econ Crop Tech Serv Stn, Haining 314400, Zhejiang, Peoples R China
4.Zhejiang Prov Ctr Dis Control & Prevent, Dept Environm & Hlth, 3399 Binsheng Rd, Hangzhou 310051, Zhejiang, Peoples R China
关键词： Sanghuangporus vaninii; aqueous extracts; S-phase arrest; apoptosis; human melanoma
期刊名称：ONCOLOGY LETTERS （ 影响因子：2.967； 五年影响因子：2.575 ）
ISSN： 1792-1074
年卷期： 2021 年 22 卷 2 期
页码：
收录情况： SCI
摘要： Sanghuangporus vaninii, also called 'Sanghuang' mushroom in Chinese, has various medicinal uses, but its effects on human melanoma cells have not been reported. The present study investigated the inhibitory ability and potential anticancer mechanism of the aqueous extracts of S. vaninii (SH). The results revealed that SH inhibited the proliferation of A375 human melanoma cells in a dose-dependent manner, and flow cytometry analysis suggested that SH induced A375 cell cycle arrest at S phase and apoptosis. Reverse transcription-quantitative PCR, western blotting and immunofluorescence analyses indicated that SH induced S-phase arrest by upregulating p21 expression, and p21 inhibited the expression of cyclin-cyclin-dependent kinases complexes at both the RNA and protein levels. In addition, SH induced apoptosis of A375 cells by inhibiting the expression levels of the anti-apoptosis gene Bcl-2. Therefore, the results suggested that SH may be a potential candidate for the treatment of human melanoma, thus providing new ideas for developing drugs that target melanoma.
- 相关文献
作者其他论文 更多>>
-
Distinguishing Sanghuangporus from sanghuang-related fungi: a comparative and phylogenetic analysis based on mitogenomes
作者：Feng, Xi-long;Xie, Tian-chen;Wang, Zhen-xin;Lin, Chao;Li, Zhao-chen;Gao, Jin-ming;Qi, Jianzhao;Huo, Jinxi;Li, Yougui;Liu, Chengwei
关键词：Comparative mitogenome; Phylogenetic analysis; Sanghuang-like fungi; Sanghuangporus
-
Development and comprehensive SBSE-GC/Q-TOF-MS analysis optimization, comparison, and evaluation of different mulberry varieties volatile flavor
作者：Ma, Di;Zhao, Huiyu;Wang, Xinquan;Di, Shanshan;Liu, Zhenzhen;Qi, Peipei;Zhang, Suling;Jiao, Rui;Ma, Di;Wang, Xinquan;Liu, Mingqi;Jiao, Rui;Lin, Tianbao;Li, Yougui;Zhao, Huiyu;Wang, Xinquan
关键词：SBSE; Mulberry varieties; Volatile compounds; OAVs; Flavor; Odor ring charts
-
Mulberry leaf supplementation inhibits skatole deposition by regulating gut microbiota and upregulating liver cytochrome P450 1A1 expression in finishing pigs
作者：Sun, Yuqing;Lin, Tianbao;Zhong, Shi;Huo, Jinxi;Lv, Zhiqiang;Li, Yougui;Men, Xiaoming;Deng, Bo;Qin, Kaipeng;Xu, Ziwei
关键词：Pig; Skatole; Mulberry leaf; Microbiota; Cytochrome P450
-
a b
作者：Zheng, Meiyu;Wang, Lu;Zhang, Wenjuan;Gao, Pu;Lu, Shengmin;Sun, Yuqing;Pi, Xionge;Liu, Wei
关键词：Phellinus baumii; STZ-induced; Hypoglycemic effect; In vitro fermentation; Intestinal flora
-
Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice
作者：Zhong, Shi;Huo, Jinxi;Sun, Yuqing;Ren, Ning;Lu, Qinhua;Li, Da;Wu, Weijie;Chen, Huizhi;Niu, Ben;Li, Qingsheng;Li, Yougui;Yang, Yanan;Wu, Chongming;Zhan, Pengfei;Pan, Meiliang;Ma, Huanyan;Liu, Qinqiao
关键词：Mulberry leaf; Mulberry tea; Lipid-lowering; Gut microbiota; Metabolomics
-
Toxicity effects of zinc supply on growth revealed by physiological and transcriptomic evidences in sweet potato (Ipomoea batatas (L.) Lam)
作者：Meng, Yusha;Xiang, Chao;Shen, Shengfa;Wu, Liehong;Meng, Yusha;Huo, Jinxi;Tang, Yong
关键词：
-
Investigation of the difference in color enhancement effect on cyanidin-3-O-glucoside by phenolic acids and the interaction mechanism
作者：Cao, Yan;Gao, Haiyan;Xia, Qile;Zhao, Baofu;Li, Yougui;Fang, Zhongxiang
关键词：Cyanidin-3-O-glucoside; Phenolic acids; Stability; Co-pigmentation effect; Molecular docking
