您好，欢迎访问北京市农林科学院 机构知识库！
北京市农林科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Metabolic responses of golden trout (Oncorhynchus mykiss aguabonita) after acute exposure to waterborne copper

文献类型： 外文期刊

作者： Chen, Yan 1 ; Cheng, Bo 2 ; Liu, Yang 3 ; Bai, Yucen 4 ; Yang, Xiaofei 1 ; Xu, Shaogang 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Fisheries Sci Inst, Beijing Key Lab Fishery Biotechnol, Beijing 100097, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Aquat Prod Proc, Minist Agr & Rural Affairs, Beijing, Peoples R China

3.Qinghai Univ, Coll Ecoenvironm Engn, Xining 810016, Peoples R China

4.China Rural Technol Dev Ctr, 54 Sanlihe Rd, Beijing 100045, Peoples R China

关键词： Copper; Metabolomics; Acute exposure

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：5.202； 五年影响因子：5.758 ）

ISSN： 0166-445X

年卷期： 2022 年 249 卷

页码：

收录情况： SCI

摘要： Despite the broad knowledge of copper-induced stress and toxicity, data on the physiological responses to acute copper exposure and the correlation of those activities to a generalized stress response are still limited. The present study aimed to assess the physiological responses of golden trout to overcome copper stress at concentrations of 60 mu g/L and 120 mu g/L after 96 h, respectively. The activities of glucose-6-phosphate dehydrogenase (G6PD) phosphoenolpyruvate carboxykinase (PEPCK) and NADPH/NADP(+) ratio were significantly increased, and metabolites including glucose 6-phosphate, fructose 1-phosphate and fatty acids significantly accumulated in fish liver, indicating that gluconeogenesis, the pentose-phosphate pathway, as well as alteration of the membrane fatty acid composition were activated to serve as a defense mechanism against 60 mu g/L of copper after 96 h. After exposure to 120 mu g/L of copper for 96 h, the NAD(+) and ATP contents, the activities of enzymes in the glycolytic pathway (phosphofructokinase, PFK and pyruvate kinase, PK) and mitochondrial respiratory chain complex I decreased significantly in fish liver. In addition, carbohydrates and MDA accumulated in golden trout after 120 mu g/L copper treatment. These results indicated that 120 mu g/L of copper exposure may induce a metabolic stress in golden trout after 96 h. The multi-marker approach allows us to reach a greater understanding of the effects of copper on physiological responses of golden trout.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：北京市农林科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台