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The ecological and molecular mechanism underlying effective reduction of antibiotic resistance genes pollution in soil by fermentation broth from fruit and vegetable waste

文献类型： 外文期刊

作者： Lin, Da 1 ; Zhu, Lin 1 ; Yao, Yanlai 3 ; Zhu, Lizhong 4 ; Wang, Meizhen 1 ;

作者机构： 1.Zhejiang Gongshang Univ, Sch Environm Sci & Engn, Hangzhou 310012, Peoples R China

2.Zhejiang Prov Key Lab Solid Waste Treatment & Recy, Hangzhou 310012, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Environm Resource Soil & Fertilizer, Hangzhou 310021, Peoples R China

4.Zhejiang Univ, Coll Environm & Resource Sci, MOE Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou 310058, Peoples R China

关键词： Antibiotic resistance genes; Fermentation broth; Actinobacteria; Selective pressure; Horizontal gene transfer

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）

ISSN： 0304-3894

年卷期： 2023 年 451 卷

页码：

收录情况： SCI

摘要： The strategies to relieve antibiotic resistance genes (ARGs) pollution are urgently needed. Fermentation broth from fruit and vegetable waste (FFVW), an agricultural amendment, exhibits a remarkable capacity to reduce ARG pollution; however, the underlying mechanism of this effect remains unclear. We performed microcosm experiments to reappear the phenomenon of FFVW-driven reduction in ARGs. Moderate-level FFVW reduced gene resistance to sulfonamide (41.2 %), macrolide-lincosamide-streptogramin (MLS) (47.2 %), chloramphen-icol (63.2 %), and tetracycline (61.4 %). Binning and network analyses revealed that Actinobacteria comprise the primary hosts of ARGs in arable soil, and FFVW substantially inhibited the growth and metabolic activity of these organisms. Moreover, tetracycline and MLS production was partially/completely inhibited by FFVW, further reducing the transfer frequency by 52.9-86.1 % and 46.6-66.6 % in the intragenic and intergenic mating sys-tems, respectively. Furthermore, the expression of genes related to conjugation pairing and plasmid transfer was downregulated. Thus, FFVW effectively reduces ARG pollution by inhibiting Actinobacteria proliferation,thereby reducing selective pressure and restricting horizontal gene transfer. Our findings highlight the important underlying mechanisms of FFVW involved in ARG reduction, supporting its use in arable soil.

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