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Effects of quercetin and coated sodium butyrate dietary supplementation in diquat-challenged pullets

文献类型： 外文期刊

作者： Zhou, Ning 1 ; Tian, Yong 2 ; Liu, Wenchao 3 ; Tu, Bingjiang 4 ; Gu, Tiantian 2 ; Xu, Wenwu 2 ; Zou, Kang 1 ; Lu, Lizhi 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Anim Sci & Vet, State Key Lab Managing Biot Safety Agroprod, Hangzhou 310000, Peoples R China

3.Huzhou Lvchang Ecoagr Co Ltd, Huzhou 313025, Peoples R China

4.Huzhou Wuxing Dist Anim Dis Prevent & Control Ctr, Huzhou 313000, Peoples R China

关键词： Pullets; Quercetin; Coated Sodium Butyrate; Oxidative Stress; Small Intestine

期刊名称：ANIMAL BIOSCIENCE

ISSN： 2765-0189

年卷期： 2022 年 35 卷 9 期

页码：

收录情况： SCI

摘要： Objective: This study was designed to investigate the hypothesis that dietary quercetin (QUE) and coated sodium butyrate (SB) supplementation alleviate oxidative stress in the small intestine of diquat (DIQ)-challenged pullets.Methods: A total of 200 13-week-old pullets were divided into four groups: the control group (CON), the DIQ group, the QUE group, and the coated SB group, and injected intraperitoneally with either saline (CON) or diquat (DIQ, QUE, and SB) to induce oxidative stress on day 0.Results: On the first day, the malondialdehyde and superoxide dismutase (SOD) concentra-tions in the SB group were significantly different from those in the DIQ and QUE groups (p<0.05), and dietary supplementation with SB increased serum glutathione peroxidase (GSH-PX) levels compared with the DIQ group (p<0.05). Quercetin and SB increased the levels of CLAUDIN-1 and zonula occludens-1 (ZO-1) in the jejunum. On the tenth day of treatment, QUE attenuated the decrease in GSH-PX levels compared to those of the CON group (p<0.05), while SB increased SOD, GSH-PX, and total antioxidant capacity levels compared to those of the DIQ group. Nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase-1 (HO-1) mRNA levels in the QUE and SB groups increased (p<0.05) and CLAUDIN-1 mRNA levels in the QUE and SB groups were upregulated compared to those in the DIQ group ileum tissue.Conclusion: Supplementation of QUE and SB demonstrated the ability to relieve oxidative stress in pullets post DIQ-injection with a time-dependent manner and QUE and SB may be potential antioxidant additives for relieving oxidative stress and protecting the intestinal barrier of pullets.

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