Nitrogen Mustard Based 2-Benzylidene-1-tetralone as ICT-Based Fluorescent Probe for Drug Release Monitoring and Cervical Cancer Therapy
文献类型： 外文期刊
作者： Liang, Yuanwei 1 ; Li, Chengpeng 1 ; Qiu, Wenhua 1 ; Li, Puwang 2 ; Yang, Ziming 2 ; Lin, Haisheng 3 ; Zhao, Yuntao 3 ;
作者机构： 1.Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China
2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
3.Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China
4.Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China
关键词： nitrogen mustard; drug release; fluorescent probe; cancer therapy
期刊名称：RUSSIAN JOURNAL OF GENERAL CHEMISTRY （ 影响因子：0.779； 五年影响因子：0.697 ）
ISSN： 1070-3632
年卷期： 2022 年 92 卷 11 期
页码：
收录情况： SCI
摘要： A series of novel intramolecular charge transfer (ICT) based 2-benzylidene-1-tetralones that contain nitrogen mustard for drug release monitoring and cervical cancer therapy were developed. Their emission wavelength and Stokes shift were up to 550 nm and 142 nm, respectively. These compounds exerted excellent anticancer activity against cervical cancer cells, among which 2-{4-[bis(2-chloroethyl)amino]benzylidene}-7-fluoro-3,4-dihydronaphthalen-1(2H)-one exerted the strongest anti-proliferation activity that inhibited HeLa cell cycle in G(2)/M phase and induced cell apoptosis, as well as activating pro-apoptotic proteins. Furthermore, the release of 2-{4-[bis(2-chloroethyl)amino]benzylidene}-7-fluoro-3,4-dihydronaphthalen-1(2H)-one probe was monitored to locate in lysosomes and nuclei.
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