Dual Enzyme-Mimic Popcorn-Shaped Copper-Erbium Nanoalloys for Combating Gram-Negative Pathogens and Promoting Wound Healing
文献类型： 外文期刊
作者： Ali, Arbab 1 ; Liu, Tao 1 ; Zhang, Jiakun 3 ; Liu, Qiaolin 1 ; Peng, Yufeng 1 ; Li, Shengmin 1 ; Shi, Kejian 4 ; Zhou, Huige 1 ;
作者机构： 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, New Cornerstone Sci Lab, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.China Agr Univ, Coll Resources & Environm Sci, Beijing Key Lab Farmland Soil Pollut Prevent & Rem, Beijing 100193, Peoples R China
3.Hebei Acad Agr & Forestry Sci, Inst Biotechnol & Food Sci, Shijiazhuang 050051, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Thorac Surg, Beijing 100053, Peoples R China
5.Chinese Acad Med Sci, Res Unit Nanosci & Technol, Beijing 100021, Peoples R China
关键词： nanoalloys; catalytic; reactive oxygen species(ROS); antibacterial; wound healing
期刊名称：ACS APPLIED NANO MATERIALS （ 影响因子：5.5； 五年影响因子：5.6 ）
ISSN：
年卷期： 2025 年 8 卷 12 期
页码：
收录情况： SCI
摘要： Nanozymes with intrinsic ROS-generating abilities hold promise as next-generation antimicrobials; however, optimizing their enzyme-mimic efficiency remains a significant challenge. Here, we fabricated popcorn-shaped copper-erbium nanoalloys (CuEr NAs) via a simple one-pot coreduction method, resulting in stabilized nanoconstructs with dual enzyme-mimic activities. We described that CuEr NAs effectively inactivate Escherichia coli (E. coli) by generating intracellular ROS and depleting glutathione (GSH) through the release of copper ions. These ions induced oxidative stress by generating hydroxyl radicals (center dot OH) in acidic environments and oxidizing GSH to glutathione disulfide (GSSG), thereby amplifying ROS generation. CuEr NAs exhibited potent antibacterial activity and enhanced wound healing efficacy in an infected wound model by reducing the bacterial load, ameliorating inflammation, and promoting tissue remodeling. Histological analysis showed enhanced collagen deposition and re-epithelialization in wounds treated with CuEr NAs, highlighting their potential as a flexible platform for antimicrobial and regenerative biomedical applications. This study highlights CuEr NAs as a viable platform for antimicrobial applications and provides insights into the fabrication of multifunctional nanoantimicrobials.
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