文献类型： 外文期刊
作者： Liu, Yuhong 1 ; Gao, Qianmei 1 ; Zhang, Qi 1 ; Li, Chen 3 ; Liu, Sha 1 ; Su, Meng 1 ; Song, Danli 1 ; Zhao, Guiping 1 ; Li, Qinghe 1 ;
作者机构： 1.Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Anim Poultry Genet Breeding & Reprod, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Biotech Breeding, Beijing 100193, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Anim Sci & Vet, Hangzhou 310021, Peoples R China
关键词： HD11; LNX1; Ubiquitination; Proteomics; Innate Immunity
期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）
ISSN： 0032-5791
年卷期： 2025 年 104 卷 1 期
页码：
收录情况： SCI
摘要： Ubiquitination of proteins is involved in numerous life activities. In poultry, several ubiquitin ligases tightly control the innate immune response, imbalance of which may result in autoimmune diseases and seriously impair poultry growth, development, and productivity. LNX1, an E3 ubiquitin ligase, catalyzes the ubiquitination and subsequent degradation of specific substrate proteins. A cell line with stable knockdown of the LNX1 gene was developed using chicken macrophages (HD11) as the model. The relative quantitative values of each protein were analyzed using 4D-FastDIA quantitative proteomics. This identified 319 proteins with up-regulated expression, a majority of which relate to the immune system. Overall, this study uncovered potential substrate proteins targeted by LNX1 and their associated biological pathways. The findings suggest that LNX1 could be implicated in the regulation of the chicken innate immune system by mediating protein ubiquitination.
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