文献类型： 外文期刊

作者： Cheng, Shifeng ¹ ; Feng, Cong ¹ ; Wingen, Luzie U. ² ; Cheng, Hong ¹ ; Riche, Andrew B. ³ ; Jiang, Mei ¹ ; Leverington-Waite, Michelle ² ; Huang, Zejian ¹ ; Collier, Sarah ² ; Orford, Simon ² ; Wang, Xiaoming ² ; Awal, Rajani ² ; Barker, Gary ⁵ ; O'Hara, Tom ² ; Lister, Clare ² ; Siluveru, Ajay ² ; Quiroz-Chavez, Jesus ² ; Ramirez-Gonzalez, Ricardo H. ² ; Bryant, Ruth ⁶ ; Berry, Simon ⁷ ; Bansal, Urmil ⁸ ; Bariana, Harbans S. ⁸ ; Bennett, Malcolm J. ¹⁰ ; Bicego, Breno ¹¹ ; Bilham, Lorelei ² ; Brown, James K. M. ² ; Burridge, Amanda ⁵ ; Burt, Chris ⁶ ; Buurman, Milika ¹² ; Castle, March ³ ; Chartrain, Laetitia ² ; Chen, Baizhi ¹ ; Denbel, Worku ¹³ ; Elkot, Ahmed F. ¹⁴ ; Fenwick, Paul ¹⁵ ; Feuerhelm, David ¹⁶ ; Foulkes, John ¹⁰ ; Gaju, Oorbessy ¹⁰ ; Gauley, Adam ¹⁷ ; Gaurav, Kumar ² ; Hafeez, Amber N. ² ; Han, Ruirui ¹ ; Horler, Richard ² ; Hou, Junliang ¹ ; Iqbal, Muhammad S. ¹ ; Kerton, Matthew ²⁰ ; Kondic-Spica, Ankica ²¹ ; Kowalski, Ania ² ; Lage, Jacob ²² ; Li, Xiaolong ²³ ; Liu, Hongbing ¹ ; Liu, Shiyan ¹ ; Lovegrove, Alison ³ ; Ma, Lingling ¹ ; Mumford, Cathy ² ; Parmar, Saroj ³ ; Philp, Charlie ² ; Playford, Darryl ² ; Przewieslik-Allen, Alexandra M. ⁵ ; Sarfraz, Zareen ¹ ; Schafer, David ⁶ ; Shewry, Peter R. ³ ; Shi, Yan ¹ ; Slafer, Gustavo A. ¹¹ ; Song, Baoxing ²⁵ ; Song, Bo ¹ ; Steele, David ³ ; Steuernagel, Burkhard ² ; Tailby, Phillip ⁷ ; Tyrrell, Simon ²⁶ ; Waheed, Abdul ¹ ; Wamalwa, Mercy N. ²⁷ ; Wang, Xingwei ¹ ; Wei, Yanping ¹ ; Winfield, Mark ⁵ ; Wu, Shishi ¹ ; Wu, Yubing ¹ ; Wulff, Brande B. H. ² ; Xian, Wenfei ¹ ; Xu, Yawen ¹ ; Xu, Yunfeng ¹ ; Yuan, Quan ¹ ; Zhang, Xin ¹ ; Edwards, Keith J. ⁵ ; Dixon, Laura ¹⁷ ; Nicholson, Paul ² ; Chayut, Noam ² ; Hawkesford, Malcolm J. ³ ; Uauy, Cristobal ² ; Sanders, Dale ² ; Huang, Sanwen ¹ ; Griffiths, Simon ² ;

作者机构： 1.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Genome Anal Lab,Minist Agr, Shenzhen Branch,Guangdong Lab Lingnan Modern Agr, Shenzhen, Peoples R China

2.John Innes Ctr, Norwich, England

3.Rothamsted Res, Harpenden, England

4.Northwest A&F Univ, Coll Agron, State Key Lab Crop Stress Biol Arid Areas, Yangling, Peoples R China

5.Univ Bristol, Sch Biol Sci, Funct Genom, Bristol, England

6.RAGT, Saffron Walden, England

7.Limagrain UK, Bury St Edmunds, England

8.Univ Sydney, Plant Breeding Inst, Sch Life & Environm Sci, Fac Sci, Cobbitty, Australia

9.Univ Western Sydney, Richmond, NSW, Australia

10.Univ Nottingham, Sch Biosci, Loughborough, England

11.Univ Lleida, AGROTECNIO CERCA Ctr, Dept Agr & Forest Sci & Engn, Lleida, Spain

12.Elsoms Wheat, Spalding, England

13.Ethiopian Inst Agr Res, Debre Zeit Agr Res Ctr, Debre Zeit, Ethiopia

14.Agr Res Ctr, Field Crops Res Inst, Wheat Res Dept, Giza, Egypt

15.Limagrain UK, Market Rasen, England

16.Syngenta Seeds, Cambridge, England

17.Univ Leeds, Sch Biol, Leeds, England

18.Agrifood & Biosci Inst, Belfast, North Ireland

19.Qingdao Agr Univ, Qingdao, Peoples R China

20.DSV UK, Banbury, England

21.Natl Inst Republ Serbia, Inst Field & Vegetable Crops, Novi Sad, Serbia

22.KWS UK, Royston, England

23.Zhejiang A&F Univ, Coll Hort Sci, Key Lab Qual & Safety Control Subtrop Fruit & Vege, Minist Agr & Rural Affairs, Hangzhou 311300, Peoples R China

24.Catalonian Inst Res & Adv Studies, ICREA, Barcelona, Spain

25.Peking Univ, Inst Adv Agr Sci, Natl Key Lab Wheat Improvement, Shandong Lab Adv Agr Sci Weifang, Weifang, Peoples R China

26.Earlham Inst, Norwich, England

27.Egerton Univ, Njoro, Kenya

28.Huazhong Agr Univ, Wuhan, Peoples R China

29.King Abdullah Univ Sci & Technol KAUST, Ctr Desert Agr, Plant Sci Program, Biol & Environm Sci & Engn Div BESE, Thuwal, Saudi Arabia

30.Max Planck Inst Biol Tubingen, Dept Mol Biol, Tubingen, Germany

31.Chinese Acad Trop Agr Sci, State Key Lab Trop Crop Breeding, Haikou, Peoples R China

期刊名称：NATURE （ 影响因子：50.5； 五年影响因子：54.4 ）

ISSN： 0028-0836

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A. E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, by whole-genome re-sequencing of 827 Watkins landraces and 208 modern cultivars and in-depth field evaluation spanning a decade. We found that modern cultivars are derived from two of the seven ancestral groups of wheat and maintain very long-range haplotype integrity. The remaining five groups represent untapped genetic sources, providing access to landrace-specific alleles and haplotypes for breeding. Linkage disequilibrium-based haplotypes and association genetics analyses link Watkins genomes to the thousands of identified high-resolution quantitative trait loci and significant marker-trait associations. Using these structured germplasm, genotyping and informatics resources, we revealed many Watkins-unique beneficial haplotypes that can confer superior traits in modern wheat. Furthermore, we assessed the phenotypic effects of 44,338 Watkins-unique haplotypes, introgressed from 143 prioritized quantitative trait loci in the context of modern cultivars, bridging the gap between landrace diversity and current breeding. This study establishes a framework for systematically utilizing genetic diversity in crop improvement to achieve sustainable food security. Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.