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Genome-Wide Association Study of Body Weights in Hu Sheep and Population Verification of Related Single-Nucleotide Polymorphisms

文献类型： 外文期刊

作者： Cao, Yuhao 1 ; Song, Xuemei 3 ; Shan, Huili 2 ; Jiang, Junfang 2 ; Xiong, Pei 1 ; Wu, Jianliang 2 ; Shi, Fangxiong 1 ; Ji 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet, Hangzhou, Peoples R China

3.Ningbo Univ, Dept Biochem & Mol Biol, Zhejiang Key Lab Pathophysiol, Med Sch, Ningbo, Peoples R China

关键词： Hu sheep; body weight; GWAS; population verification; transcriptional activity

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： Body weight (BW) is a critical economic trait for meat production in sheep. The current study aimed to perform a genome-wide association study (GWAS) to detect significant single-nucleotide polymorphisms (SNPs) that are associated with BW in Hu sheep. The comparison and analysis of the G1 and G2 generations of a nucleus meat Hu sheep breeding herd revealed four SNPs identified by GWAS. The subsequent verification of the significant SNP loci in the Hu sheep G3 generation nucleus herd also detected nine SNPs in significant SNP regions. Two SNPs were significantly associated with the BW of Hu sheep (p< 0.05). OARX_76354330.1 and s64890.1 could be identified as functional SNPs for the growth traits of Hu sheep.CAPN6, as a candidate gene, was significantly different in the biceps femoris and longissimus dorsi muscles of weaning (60-day) and 6-month sheep, which facilitated the discovery of causal variants for BW and contributed to the marker-assisted selection breeding of Hu sheep.

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