A pair of newneo-clerodane diterpenoid epimers from the roots ofCroton crassifoliusand their anti-inflammatory
文献类型： 外文期刊
作者： Zhang, Dong-Bo 1 ; Tang, Zhi-Shu 1 ; Xie, Pei 1 ; Liang, Yan-Ni 1 ; Yu, Jin-Gao 1 ; Zhang, Zhen 1 ; Duan, Dong-Zhu 2 ; Cu 1 ;
作者机构： 1.Shaanxi Univ Chinese Med, Shaanxi Prov Key Lab New Drugs & Chinese Med Fdn, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Xianyang, Peoples R China
2.Bao Ji Univ Arts & Sci, Baoji, Peoples R China
3.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Danzhou 571737, Peoples R China
关键词： Euphorbiaceae; Croton crassifolius; clerodane diterpenoid; anti-inflammatory activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期： 2020 年 34 卷 20 期
页码：
收录情况： SCI
摘要： A pair of newneo-clerodane diterpenoid epimers, 3S-methoxyl-teucvin (1) and 3R-methoxyl-teucvin (2), were isolated from the Roots ofCroton crassifolius.Their structures were completely established on the basis of spectroscopic methods, and the absolute configurations were determined by analysis of electronic circular dichroism (ECD) spectroscopy and X-ray diffraction analysis. Compounds1and2exhibited anti-inflammatory activities with IC(50)values of 0.82 and 0.54 mu M, respectively, while the IC(50)value of dexamethasone as a positive control was found to be 0.14 mu M.
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