D-mannose-modified nanoliposomes enhance the targeted delivery of ovalbumin to improve its anti-inflammatory, antioxidant, and macrophage polarization effects
文献类型： 外文期刊
作者： Liao, Jiahao 1 ; Huang, Jianyu 2 ; Chi, Xiaoyi 1 ; Li, Xiaoqiong 2 ; Kuang, Jian 2 ; Li, Jianqiang 2 ; Bian, Xiangyu 2 ; Pang, Jinzhu 3 ; Li, Jinjun 2 ; Wang, Weiwei 1 ;
作者机构： 1.Shanxi Agr Univ, Coll Anim Sci, Taigu 030801, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Food Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
3.Inner Mongolia Mengniu Dairy Grp Co Ltd, Global R&D Innovat Ctr, Mengniu Inst Nutr Sci, Hohhot, Peoples R China
4.Shanxi Key Lab Anim Genet Resource Utilizat & Bree, Taigu 030801, Peoples R China
关键词： D-mannose nanoliposome; Ovalbumin delivery; Macrophage targeting; Anti-inflammatory effects
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.0； 五年影响因子：4.9 ）
ISSN： 1756-4646
年卷期： 2025 年 124 卷
页码：
收录情况： SCI
摘要： In this study, D-mannose-modified nanoliposomes (MLipo@OVA) were developed to facilitate the targeted delivery of ovalbumin (OVA) to macrophages. The subsequent anti-inflammatory, antioxidant, and macrophagepolarizing effects of OVA were investigated. The nanoliposomes were designed with DSPE-PEG and DPPC to enhance the bioavailability and stability of OVA. In vitro analysis showed that MLipo@OVA significantly increased macrophage uptake, with D-mannose further enhancing this effect. MLipo@OVA reduced proinflammatory cytokines (TNF-alpha, IL-1 beta) and increased anti-inflammatory IL-10 levels in LPS-induced macrophages, primarily via the inhibition of the TLR4/NF-kappa B pathway. Furthermore, ROS levels were decreased, SOD and GSH activity was enhanced, the Nrf2/HO-1 pathway was activated, and the compound exhibited strong antioxidant activity. MLipo@OVA also promoted M2 macrophage polarization by upregulating CD206 and Arg-1 and downregulating iNOS. Overall, these results indicate that MLipo@OVA could be used as a nanomedicine to facilitate targeted anti-inflammatory and antioxidant therapies.
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