文献类型： 外文期刊
作者： Li, Zhen 1 ; Mei, Shunqi 1 ; Dong, Yajie 1 ; She, Fenghua 2 ; Li, Puwang 4 ; Li, Yongzhen 5 ; Kong, Lingxue 2 ;
作者机构： 1.Wuhan Text Univ, Hubei Key Lab Digital Text Equipment, Wuhan 430073, Peoples R China
2.Deakin Univ, Inst Frontier Mat, Geelong, Vic 3216, Australia
3.Xiangtan Univ, Foshan Green Intelligent Mfg Res Inst, Foshan 528000, Peoples R China
4.Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524091, Peoples R China
5.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
关键词： core-shell nanofiber; drug delivery; co-axial centrifugal spinning; wound healing
期刊名称：NANOMATERIALS （ 影响因子：5.076； 五年影响因子：5.346 ）
ISSN：
年卷期： 2021 年 11 卷 6 期
页码：
收录情况： SCI
摘要： Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.
- 相关文献
作者其他论文 更多>>
-
Performance of Moringa Oil as an Effective Bioplasticizer on Static and Dynamic Mechanical Properties of Natural Rubber Vulcanizates
作者：Jarnthong, Methakarn;Li, Yongzhen;Yu, Heping;Wang, Rui;Wang, Yueqiong;Liu, Hongchao;Liao, Lusheng;Peng, Zheng;Lopattananon, Natinee;Peng, Zheng
关键词：Moringa oil; Natural rubber; Bioplasticizer; Static properties; Dynamic mechanical properties; Vulcanizates
-
Chromosome-level genome assembly of Pedicularis kansuensis illuminates genome evolution of facultative parasitic plant
作者：Fang, Longfa;Li, Mingyu;Zhang, Jia;Jia, Chenglin;Qiang, Yuqing;He, Xiaojuan;Liu, Tao;Zhou, Qiang;Luo, Dong;Liu, Wenxian;Liu, Zhipeng;Han, Yuling;Li, Zhen;Yang, Yongzhi;Liu, Jianquan
关键词：facultative parasite; gene loss; genome assembly; horizontal gene transfer; mobile mRNAs
-
A triple-signal strategy separated aptasensor for sensitive determination of aflatoxin B1 in peanut based on electrochemical and fluorescent dual-mode
作者：He, Zuyu;Zhang, Mengru;Yang, Ziming;Zhou, Chuang;Wang, Chao;Song, Shuhui;Liu, Yunhao;Chen, Shaohua;Li, Puwang;Zhang, Mengru
关键词：Dual-mode; Triple-signal; Aptasensor; Electrochemical; Fluorescent; Aflatoxin B1
-
Enhanced mechanical properties and antibacterial activities of chitosan films through incorporating zein-gallic acid conjugate stabilized cinnamon essential oil Pickering emulsion
作者：Yang, Linjie;Zhou, Chuang;Liu, Yunhao;He, Zuyu;Zhang, Mengru;Wang, Chao;Yang, Ziming;Li, Puwang;Yang, Linjie;Zhang, Mengru
关键词：Active packaging; Chitosan; Zein; Cinnamon essential oil; Pickering emulsions
-
Mechanical and Degradation Properties of Degradable Cover Materials for Sugarcane Leaves
作者：Jiaoa, Jing;Huang, Xiaohong;Du, Jihua;Zhou, Yirong;Jiaoa, Jing;Song, Shuhui;Li, Puwang;Huang, Xiaohong;Liu, Xinpeng;Song, Shuhui;Zhou, Yirong
关键词：Sugarcane leaves; Degradable; Material properties
-
Glycosyltransferase Slr1064 regulates carbon metabolism by modulating the levels of UDP-GlcNAc in Synechocystis sp. PCC 6803
作者：Han, Yuling;Xu, Congzhuo;Liu, Zhipeng;Fang, Longfa;Han, Yuling;Ge, Haitao;Huang, Xiahe;Zhang, Yuanya;Wang, Yingchun;Zeng, Gang;Li, Zhen
关键词：Calvin cycle; CP12; glycosyltransferases; Synechocystis; turnover rate; UDP-GlcNAc
-
Amphiphilic chitosan/carboxymethyl gellan gum composite films enriched with mustard essential oil for mango preservation
作者：Yang, Ziming;Guan, Chen;Zhou, Chuang;Pan, Qingyan;He, Zuyu;Wang, Chao;Liu, Yunhao;Song, Shuhui;Li, Puwang;Guan, Chen;Pan, Qingyan;Yu, Lijuan;Qu, Yunhui
关键词：Amphiphilic chitosan; Carboxymethyl gellan gum; Mustard essential oil; Composite films; Fruit preservation
