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Fabrication, characterization and in vitro controlled-releasing of naringin nano-particles encapsulated by chitosan-carboxymethyl konjac glucomannan

文献类型： 外文期刊

作者： Wei, Yanjun 1 ; Xiao, Chaogeng 1 ; Lu, Wenjing 1 ; Chen, Di 1 ; Zhang, Cen 1 ; Xu, Xiaogang 2 ; Tang, Weimin 1 ; Zhao, Zhenlei 2 ;

作者机构： 1.Food Sci Inst, Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

2.Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr & Geriatr Inst Zheji, Dept Geriatr, Hangzhou 310058, Peoples R China

3.Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310052, Zhejiang, Peoples R China

4.Zhejiang Univ, Taizhou Hosp, Taizhou 317099, Zhejiang, Peoples R China

关键词： Nanoparticles; Naringin; Chitosan; Carboxymethyl konjac glucomannan; Controlled -releasing effect

期刊名称：LWT-FOOD SCIENCE AND TECHNOLOGY （ 影响因子：6.0； 五年影响因子：6.0 ）

ISSN： 0023-6438

年卷期： 2024 年 200 卷

页码：

收录情况： SCI

摘要： Naringin (NR) is a prominent citrus bioflavonoid, but the application is greatly limited by its low bioavailability. To solve this problem, NR was encapsulated in carboxymethyl konjac glucomannan (CKGM) and chitosan (CS) to form core-shell nanoparticles (CS/CKGM-NR NPs). The physicochemical properties of CS/CKGM-NR NPs with ideal encapsulation efficiency of 82.70 +/- 0.30% were characterized by fourier transform infrared spectroscopy and differential scanning calorimetry. The morphology and core-shell structure of CS/CKGM-NR NPs were observed to be successful formation (diameter 700 nm, +35 mV). Moreover, the releasing behavior of NR was evaluated in In Vitro digestion mode. The underlying mechanism indicated that carboxyl groups of CKGM were cross-linked with ammonium ion of CS by electrostatic interaction. Moreover, the releasing efficiency of NR in simulated gastric fluid (SGF, 20.62 +/- 0.59%), simulated intestinal fluid (SIF, 17.08 +/- 0.01%) and simulated colon fluid (SCF, 18.82 +/- 0.61%) were greatly lowered compared with that of naked NR (52.70 +/- 0.01% in SGF, 46.42 +/- 3.30% in SIF, 69.35 +/- 12.63% in SCF). The findings implied that CS/CKGM-NR NPs were created in core-shell structure with controlled-releasing effect. This study provided new insight into the fabrication of CS/ CKGM-NR NPs that could be developed as a potential nano-delivery with controlled-releasing effect.

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