文献类型： 外文期刊

作者： Wang, De-Lei ¹ ; Lin, Fang-Xia ¹ ; Tang, Min-Min ¹ ; Zhou, Xue-Ming ¹ ; Yi, Ji-Ling ¹ ; Wang, Tian-Tian ¹ ;

作者机构： 1.Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Resource Chem, Haikou 571158, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Coconut Res Inst, Wenchang 571339, Hainan, Peoples R China

3.Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China

关键词： Pholidota chinensis; Phenanthrenes; Cytotoxic activity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2021 年 43 卷

页码：

收录情况： SCI

摘要： Two new phenanthrene derivatives, 2,3,7-trihydroxy-5H-phenanthro[4,5-bcd] pyran (1) and 2,3-dihydroxy-7methoxy-5H-phenanthro[4,5-bcd] pyran (2) together with four known phenanthrenes derivatives (3-6) were isolated from the aerial parts of Pholidota chinensis Lindl. The structure of the new compounds 1 and 2 was determined by 1D and 2D NMR, as well as HRESIMS. The inhibitory activities of all compounds against four cancer cell lines were evaluated. Compounds 1 and 3 showed the highest cytotoxicity against the MCF-7 cell lines (IC50 = 8.1 and 7.5 mu M). The other compounds showed modest activities or were inactive.