Toxic effects of triphenyltin on the silkworm Bombyx mori as a lepidopterous insect model
文献类型： 外文期刊
作者： Chen, Xuedong 1 ; Zhang, Xing 2 ; Ye, Aihong 1 ; Wu, Xuehui 1 ; Cao, Jinru 1 ; Zhou, Wenlin 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Peoples R China
2.Soochow Univ, Sch Biol & Basic Med Sci, Suzhou 215123, Peoples R China
关键词： Triphenyltin; Bombyx mori; Midgut; Gene expression pattern; Metabolite
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：7.129； 五年影响因子：7.284 ）
ISSN： 0147-6513
年卷期： 2022 年 247 卷
页码：
收录情况： SCI
摘要： Triphenyltin (TPT) is a widely used reagent in various industries and agriculture, but is also known to accu-mulate in natural ecosystems and animal tissues. Hence, the aim of this study was to comprehensively assess the toxicity of TPT in the silkworm Bombyx mori as a model insect. The results showed that TPT exposure for the entire 5th instar larval stage significantly reduced the weight of silkworm pupa and inhibited development of the silkworm midgut. Following exposure to 2 mu g/kg of TPT for 4 days, differentially expressed genes in midgut were associated with enriched pathways involved in the metabolism of carbohydrates, lipids, and amino acids, as determined by RNA sequencing. Furthermore, the metabolic profiles of the intestinal content of silkworms exposed to 2 mu g/kg of TPT for 4 days were markedly altered and differential metabolites produced by metabolism of carbohydrates, lipids, and amino acids were enriched as determined by non-targeted GC-MS/MS metab-olomics. This study provides novel insights into the mechanisms underlying the toxicity of TPT and emphasizes the risks posed by such pollutants released into the environment.
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