文献类型： 外文期刊

作者： Ouyang Qianqian ¹ ; Kong Songzhi ⁴ ; Huang Yongmei ¹ ; Ju Xianghong ⁴ ; Li Sidong ⁴ ; Li Puwang ⁵ ; Luo Hui ¹ ;

作者机构： 1.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang 524023, Peoples R China

2.Southern Marine Sci & Engn Guangdong Lab Zhanjian, Zhanjiang 524023, Peoples R China

3.Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang 524023, Peoples R China

4.Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China

5.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

关键词： Hydroxyapatite; Chitosan; Tilapia peptides; Burn healing; VEGF

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2021 年 181 卷

页码：

收录情况： SCI

摘要： There is an urgent need for wound dressings to treat partial-thickness burns. Hydrogels are a promising material that can maintain hydration to promote necrotic tissue removal. Tilapia peptides (TP) and hydroxyapatite (HA) were incorporated into chitosan system to prepare new types of hydrogels. The hydrogels were cross-linking by tannin (TA), which were developed to promote rapid wound healing in a New Zealand rabbit partial-thickness burn model. Nanohydroxyapatite (NHA) was synthesized by coprecipitation method, which made hydrogels have a highly porous structure comprised of interconnected pores, excellent water absorption and low hemoly-sis. Besides, the hydrogels showed excellent antimicrobial activities against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), as well as the cytocompatibility on endothelial cells. Moreover, the hydrogels promoted epithelial and dermal regeneration, reduce the expression of TNF-alpha and IL-6 and promote the skin re-generation by enhancing expression of collagen, STAT3, and VEGF. (c) 2021 Published by Elsevier B.V.