文献类型： 外文期刊

作者： Xu, Ming-Min ¹ ; Gu, Li-Hong ⁴ ; Lv, Wan-Yue ¹ ; Duan, Sheng-Chang ⁶ ; Li, Lian-Wei ³ ; Du, Yuan ⁶ ; Lu, Li-Zhi ⁸ ; Zeng, Tao ⁸ ; Hou, Zhuo-Cheng ⁹ ; Ma, Zhanshan Sam ³ ; Chen, Wei ¹¹ ; Adeola, Adeniyi C. ¹ ; Han, Jian-Lin ¹³ ; Xu, Tie-Shan ¹⁵ ; Dong, Yang ¹¹ ; Zhang, Ya-Ping ¹ ; Peng, Min-Sheng ¹ ;

作者机构： 1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China

2.Chinese Acad Sci, Kunming Inst Zool, Yunnan Lab Mol Biol Domest Anim, Kunming 650223, Peoples R China

3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Peoples R China

4.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou 571100, Peoples R China

5.Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources Yu, Kunming 650091, Peoples R China

6.Nowbio Biotechnol Co, Kunming 650201, Peoples R China

7.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Computat Biol & Med Ecol Lab, Kunming 650223, Peoples R China

8.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Peoples R China

9.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, MARA, Beijing 100193, Peoples R China

10.China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, MARA, Beijing 100193, Peoples R China

11.Yunnan Agr Univ, State Key Lab Conservat & Utilizat Bioresources Yu, Kunming 650201, Peoples R China

12.Yunnan Agr Univ, Minist Educ, Key Lab Agrobiodivers & Pest Control, Kunming 650201, Peoples R China

13.Chinese Acad Agr Sci CAAS, Inst Anim Sci, CAAS ILRI Joint Lab Livestock & Forage Genet Resou, Beijing 100193, Peoples R China

14.Int Livestock Res Inst ILRI, Livestock Genet Program, Nairobi 00100, Kenya

15.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Res Inst, Haikou 571101, Peoples R China

16.Chinese Acad Sci, Kunming Inst Zool, KIZ CUHK Joint Lab Bioresources & Mol Res Common D, Kunming 650223, Peoples R China

关键词： Fatty liver; Muscovy duck; Genome assembly; Evolutionary by-product; Accelerated CNEs

期刊名称：GENOMICS （ 影响因子：4.31； 五年影响因子：4.38 ）

ISSN： 0888-7543

年卷期： 2022 年 114 卷 6 期

页码：

收录情况： SCI

摘要： The Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid beta-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver.