An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence in Streptococcus suis
文献类型： 外文期刊
作者： Gu, Qibing 1 ; He, Peijuan 1 ; Wang, Dan 1 ; Ma, Jiale 1 ; Zhong, Xiaojun 1 ; Zhu, Yinchu 1 ; Zhang, Yue 1 ; Bai, Qiankun 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing, Peoples R China
2.Minist Agr, Key Lab Anim Bacteriol, Nanjing, Peoples R China
3.OIE Reference Lab Swine Streptococcosis, Nanjing, Peoples R China
4.Zhejiang A&F Univ, Coll Anim Sci & Technol, Coll Vet Med, Hangzhou, Peoples R China
5.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou, Peoples R China
6.Henan Agr Univ, Coll Vet Med, Zhengzhou, Peoples R China
关键词： Streptococcus suis; toxin; antitoxin; drug resistance; virulence
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）
ISSN：
年卷期： 2021 年 12 卷
页码：
收录情况： SCI
摘要： Toxin-antitoxin (TA) systems are ubiquitous genetic elements that play an essential role in multidrug tolerance and virulence of bacteria. So far, little is known about the TA systems in Streptococcus suis. In this study, the Xress-MNTss TA system, composed of the MNTss toxin in the periplasmic space and its interacting Xress antitoxin, was identified in S. suis. beta-galactosidase activity and electrophoretic mobility shift assay (EMSA) revealed that Xress and the Xress-MNTss complex could bind directly to the Xress-MNTss promoter as well as downregulate streptomycin adenylyltransferase ZY05719_RS04610. Interestingly, the Xress deletion mutant was less pathogenic in vivo following a challenge in mice. Transmission electron microscopy and adhesion assays pointed to a significantly thinner capsule but greater biofilm-formation capacity in Delta Xress than in the wild-type strain. These results indicate that Xress-MNTss, a new type II TA system, plays an important role in antibiotic resistance and pathogenicity in S. suis.
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