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Evolutionary conservation of Trichomonas-mycoplasma symbiosis across the host species barrier

文献类型： 外文期刊

作者： Bailey, Nicholas P. 1 ; Shao, Yuxin 2 ; Du, Shaodua 2 ; Foster, Peter G. 3 ; Fettweis, Jennifer 4 ; Hall, Neil 5 ; Wang, Zheng 2 ; Hirt, Robert P. 1 ;

作者机构： 1.Newcastle Univ, Biosci Inst, Newcastle Upon Tyne, England

2.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing, Peoples R China

3.Nat Hist Museum, London, England

4.Virginia Commonwealth Univ, Richmond, VA USA

5.Earlham Inst, Norwich, England

6.Univ East Anglia, Sch Biol Sci, Norwich, Norfolk, England

关键词： Trichomonas gallinae; Trichomonas vaginalis; Candidatus Malacoplasma/Mycoplasma girerdii; new bacteria species; Candidatus Malacoplasma/Mycoplasma trichamica; metagenomics; metatranscriptomics; phylogenetics

期刊名称：FRONTIERS IN MICROBIOLOGY （ 2022影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Introduction The protozoan parasite Trichomonas vaginalis is the most common cellular sexually transmitted disease in humans, and the closely related species Trichomonas gallinae is an avian parasite of ecological and economic importance. Phylogenetic evidence suggests T. vaginalis arose during bird to human transmission of a T. gallinae-like ancestor. Trichomonas vaginalis shares a strong clinical association with the independent sexually transmitted pathogen Metamycoplasma (formerly Mycoplasma) hominis, and the uncultured bacterium "Candidatus Malacoplasma (formerly Mycoplasma) girerdii," with the latter association being an order of magnitude stronger. Both bacterial species have been shown to profoundly influence T. vaginalis growth, energy production and virulence-associated mechanisms.Methods Evidence for a novel Malacoplasma sp. was discovered by in vivo Illumina metatranscriptomics sequencing of the T. gallinae-infected pigeon mouth. We leveraged published 16S rDNA profiling data from digestive tract of 12 healthy and 24 T. gallinae-infected pigeons to investigate association between the novel Malacoplasma sp. and T. gallinae. We utilised Illumina metagenomics sequencing targeted to pigeon oral and crop samples infected with the novel Malacoplasma sp. to generate its full-length genome sequence. Sequence similarity network analysis was used to compare annotated proteins from the novel Malacoplasma sp. with a range of other related species.Results Here we present evidence for a novel Malacoplasma species, related to "Ca. M. girerdii," that is strongly associated with T. gallinae in the upper digestive tract of domestic pigeons. Analysis of the genome sequence revealed gene features apparently specific to a Trichomonas-symbiotic Malacoplasma lineage.Discussion These data support a model of long-term association between Trichomonas and Malacoplasma spp. that has been conserved across diversification of the Trichomonas lineage and the host species barrier from birds to human.

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