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An inactivated bivalent vaccine effectively protects turbot (Scophthalmus maximus) against Vibrio anguillarum and Vibrio harveyi infection

文献类型： 外文期刊

作者： Zhang, Jian 1 ; Hu, Yonghua 3 ; Sun, Qinglei 1 ; Li, Xuepeng 2 ; Sun, Li 1 ;

作者机构： 1.Chinese Acad Sci, CAS Ctr Ocean Mega Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China

2.Yantai Univ, Sch Ocean, Yantai, Peoples R China

3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China

4.Hainan Acad Trop Agr Resource, CATAS, Inst Trop Biosci & Biotechnol, Haikou, Hainan, Peoples R China

5.Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China

关键词： Bivalent vaccine; Vibriosis; Relative percentage survival (RPS); Specific immune response; Monocytes

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2021 年 544 卷

页码：

收录情况： SCI

摘要： Vibrio anguillarum and Vibrio harveyi are two important pathogens that affect a wide range of fish species. In this study, we developed a formalin-inactivated whole-cell bivalent vaccine (named IVVah1) against V. anguillarum and V. harveyi and examined its effect in a turbot model. The results showed that when administered via a single intraperitoneal (i.p.) injection, the vaccine induced high rates of relative percentage survival (RPS) against V. anguillarum and V. harveyi from the third week post-vaccination (wpv). The RPS reached 94.74% and 91.89% against V. anguillarum and V. harveyi, respectively, at 4 wpv, and remained high (>80%) till at least 8 wpv. Specific antibodies were produced in the vaccinated fish at 1 wpv and peaked at 2 to 3 wpv. Secondary antigen exposure induced strong proliferation of peripheral blood leukocytes (PBLs) and increased the number of monocytes in PBLs. Compared to the control fish, the vaccinated fish exhibited normal growth rates and were able to thoroughly clear the challenging bacterial pathogens from tissues. These findings indicate that IVVah1 is a highly protective bivalent vaccine with a good potential to be used in aquaculture against V. anguillarum and V. harveyi infection.

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