文献类型： 外文期刊

作者： Sun, Jing ¹ ; Liu, Peng-Fei ¹ ; Liu, Jia-Ni ¹ ; Lu, Cong ¹ ; Tong, Li-Tao ¹ ; Wang, Yong-Quan ¹ ; Liu, Jia-Meng ¹ ; Fan, Bei ¹ ; Wang, Feng-Zhong ¹ ;

作者机构： 1.Chinese Acad Agr Sci, Inst Agr Prod Proc, Minist Agr & Rural Affairs, Risk Assessment Lab Agr Prod Proc Qual & Safety,Ke, Beijing, Peoples R China

2.Gansu Acad Agr Sci, Agr Prod Storage & Proc Inst, Lanzhou, Peoples R China

3.Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China

关键词： Dendrobium fimbriatum; gastric mucosal injury; metabolomics; proteomics; pathway

期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：5.988； 五年影响因子：6.455 ）

ISSN：

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： As a dietary and medicinal plant, Dendrobium fimbriatum (DF) is widely utilized in China for improving stomach disease for centuries. However, the underlying mechanisms against gastric mucosal injury have not been fully disclosed. Here, metabolomics and proteomics were integrated to clarify the in-depth molecular mechanisms using cyclophosphamide-induced gastric mucosal injury model in mice. As a result, three metabolic pathways, such as creatine metabolism, arginine and proline metabolism, and pyrimidine metabolism were hit contributing to DF protective benefits. Additionally, gamma-L-glutamyl-putrescine, cytosine, and thymine might be the eligible biomarkers to reflect gastric mucosal injury tatus, and DF anti-gastric mucosal injury effects were mediated by the so-called target proteins such as Ckm, Arg1, Ctps2, Pycr3, and Cmpk2. This finding provided meaningful information for the molecular mechanisms of DF and also offered a promising strategy to clarify the therapeutic mechanisms of functional foods.