Immunomodulation of thymus by Cistanche deserticola polysaccharides analyzed via transcription-associated proteomic techniques
文献类型： 外文期刊
作者： Zhao, Baotang 1 ; Wang, Shengfang 1 ; Tao, Faqin 2 ; Ma, Xuemei 1 ; Zhang, Jing 1 ; Li, Guofeng 3 ; Li, Mingze 3 ; Huang, Yulong 3 ;
作者机构： 1.Gansu Agr Univ, Coll Food Sci & Engn, 1 Yingmen village, Lanzhou 730070, Gansu, Peoples R China
2.Northwest Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China
3.Gansu Acad Agr Sci, Inst Agr Prod Storage & Proc, Lanzhou 730070, Peoples R China
关键词： Cistanche deserticola polysaccharides; Immunomodulatory; Transcriptome; Proteomics
期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：6.2； 五年影响因子：6.2 ）
ISSN： 0926-6690
年卷期： 2025 年 234 卷
页码：
收录情况： SCI
摘要： The aim of this study was to investigate the mechanism of immunomodulatory effects of Cistanche deserticola polysaccharide (CDP-D2-N1) on cyclophosphamide (CTX)-induced immune injury in mice. A model of CTXinduced immune injury in mice was established, and the effects of CDP-D2-N1 on body weight, thymic index, cytokines, oxidative stress products and oxidoreductase were evaluated. Meanwhile, transcriptomics and proteomics were applied for joint analysis. The results showed that CDP-D2-N1 inhibited body weight loss, increased organ index, enhanced the expression of anti-inflammatory factors, and increased the activities of GR, SOD, and CAT enzymes in immune injury mice. Through the multi-omics study, CDP-D2-N1 reversed CTX-induced immune injury, promoted functional recovery of Th17 cells, and produced immunomodulatory effects on mouse thymus. This finding provides a theoretical reference for the development of polysaccharides as natural immunomodulators.
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