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Optimization of Mycelia Selenium Polysaccharide Extraction from Agrocybe cylindracea SL-02 and Assessment of their Antioxidant and Anti-Ageing Activities

文献类型： 外文期刊

作者： Liu, Min 1 ; Jing, Huijuan 2 ; Zhang, Jianjun 2 ; Che, Gen 3 ; Zhou, Meng 4 ; Gao, Zheng 2 ; Li, Shangshang 2 ; Ren, Zhen 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Beijing Engn Res Ctr Edible Mushroom, Key Lab Urban Agr North, Inst Plant & Environm Protect,Minist Agr, Beijing, Peoples R China

2.Shandong Agr Univ, Coll Life Sci, Tai An, Shandong, Peoples R China

3.Shandong Acad Agr Sci, Jinan, Peoples R China

4.Qual & Safety Monitoring Ctr Anim Prod, Jinan, Peoples R China

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2016 年 11 卷 8 期

页码：

收录情况： SCI

摘要： The aim of the present study was to optimize the purification of mycelia selenium polysaccharides (MSPS) from Agrocybe cylindracea SL-02 and characterize their in vitro antioxidant and in vivo anti-ageing activities. The Box-Behnken experimental design (BBD) was evaluated, which showed that the optimum conditions included an extraction temperature of 94.99 degrees C, a pH of 9 and a precipitation temperature of 12 degrees C, and the predicted yield was 11.036 +/- 0.31%. The in vitro antioxidant assay demonstrated that MSPS had potential effects on scavenging and enhanced the reducing power of reactive oxygen species. The in vivo anti-ageing evaluation showed that MSPS significantly reduced the malonaldehyde (MDA) contents and total cholesterol (CHOL) levels, and remarkably improved the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC) in mice in response to D-galactose-induced ageing. Furthermore, the characteristic analysis of MSPS indicated a selenium content of 1.76 +/- 0.10 mg/g at a concentration of 6 mu g/mL in liquid media and a monosaccharide composition of rhamnose, arabinose, mannose, glucose and galactose at a molar ratio of 29:3:1:18.8:2.7. These results suggest that MSPS might be suitable for functional foods and natural drugs on preventing the ageing progress induced by toxic chemicals.

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