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alpha(v)beta(3) Integrin may Participate in Conceptus Attachment by Regulating Morphologic Changes in the Endometrium during Peri-implantation in Ovine

文献类型： 外文期刊

作者： Wan, P-C 1 ; Bao, Z-J 1 ; Wu, Y. 1 ; Yang, L. 1 ; Hao, Z-D 1 ; Yang, Y-L 2 ; Shi, G-Q 2 ; Liu, Y. 3 ; Zeng, S-M 1 ;

作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, Anim Husb & Vet Inst, Shihezi, Xinjiang, Peoples R China

3.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing, Peoples R China

期刊名称：REPRODUCTION IN DOMESTIC ANIMALS （ 影响因子：2.005； 五年影响因子：2.154 ）

ISSN： 0936-6768

年卷期： 2011 年 46 卷 5 期

页码：

收录情况： SCI

摘要： The objective of this study was to determine expression and potential functions of alpha(v) and beta(3) integrin subunits in ovine endometrium during the peri-implantation period (days 8-17 after fertilization). The morphologic changes in the endometrium were observed histochemically following haematoxylin/eosin (HE) staining, whereas the expressions of alpha(v) and beta(3) integrin subunits were analysed by RT-PCR, immunohistochemistry and Western blot. The filamentous conceptus attached to the luminal epithelium (LE) on day 17 of pregnancy, with no differences in endometrial morphology between days 8-12 of pregnancy. However, endometrial glands in the endometrial stroma (S) underwent extensive hyperplasia from day 14 to day 17, increased reductus of the LE with an obvious proliferation of caruncles, and an increased number and diameter of blood vessels (V) in the endometrium. The relative expression levels of alpha(v) and beta(3) integrin subunits mRNA gradually increased until day 16, but sharply declined on day 17. Western blot analysis revealed that the expression pattern of alpha(v) and beta(3) integrin subunit proteins paralleled that of the corresponding mRNA. In addition, immunohistochemical localization of alpha(v) and beta(3) integrin subunits confirmed their presence in the glandular epithelium (GE), LE and endometrial stroma. Immunostaining on LE and stroma varied with the increasing days of pregnancy, with the strongest immunostaining on days 16 and 17. In conclusion, expression of alpha(v) and beta(3) integrin subunits was closely related to the early progression of pregnancy and conceptus attachment; therefore, we inferred that alpha(v)beta(3) integrin may participate in conceptus attachment by the regulation of endometrial morphology during peri-implantation in ovine.

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