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Inhibiting Effect of Bioactive Metabolites Produced by Mushroom Cultivation on Bacterial Quorum Sensing-Regulated Behaviors

文献类型： 外文期刊

作者： Zhu, Hu 1 ; Wang, Shou-xian 3 ; Zhang, Shuai-shuai 2 ; Cao, Chun-xu 2 ;

作者机构： 1.China Univ Petr E China, State Key Lab Heavy Oil Proc, Dongying 257061, Peoples R China

2.China Univ Petr E China, Ctr Bioengn & Biotechnol, Qingdao, Peoples R China

3.Beijing Acad Agr & Forestry Sci, Inst Plant & Environm Protect, Beijing, Peoples R China

关键词： Bioactive metabolites;Chromobacterium violaceum CV026;Mushroom;N-Hexanoyl-L-homoserine lactone;Anti-quorum sensing;Violacein

期刊名称：CHEMOTHERAPY （ 影响因子：2.544； 五年影响因子：2.065 ）

ISSN： 0009-3157

年卷期： 2011 年 57 卷 4 期

页码：

收录情况： SCI

摘要： Aims: This study aimed to search for novel quorum sensing (QS) inhibitors from mushroom and to analyze their inhibitory activity, with a view to their possible use in controlling detrimental infections. Methods: The bioactive metabolites produced by mushroom cultivation were tested for their abilities to inhibit QS-regulated behavior. All mushroom strains were cultivated in potato-dextrose medium by large-scale submerged fermentation. The culture supernatant was condensed into 0.2 vol by freeze-drying. The condensed supernatant was sterilized by filtration through a 0.22-mu m membrane filter and added to Chromobacterium violaceum CV026 cultures, which were used to monitor QS inhibition. Inhibitory activity was measured by quantifying violacein production using a microplate reader. Results: The results have revealed that, of 102 mushroom strains, the bioactive metabolites produced by 14 basidiomycetes were found to inhibit violacein production, a QS-regulated behavior in C. violaceum. Conclusions: Higher fungi can produce QS-inhibitory compounds. Copyright (C) 2011 S. Karger AG, Basel

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[1]Evaluation of Anti-Quorum-Sensing Activity of Fermentation Metabolites from Different Strains of a Medicinal Mushroom, Phellinus igniarius. Zhu, Hu,Liu, Wei,Tian, Bao-zhen,Zhang, Shuai-shuai,Wang, Shou-xian. 2012

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