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Butyrate, Forskolin, and Lactose Synergistically Enhance Disease Resistance by Inducing the Expression of the Genes Involved in Innate Host Defense and Barrier Function

文献类型： 外文期刊

作者： Yang, Qing 1 ; Whitmore, Melanie A. 1 ; Robinson, Kelsy 1 ; Lyu, Wentao 1 ; Zhang, Guolong 1 ;

作者机构： 1.Oklahoma State Univ, Dept Anim & Food Sci, Stillwater, OK 74078 USA

2.USDA ARS, Poultry Prod & Prod Safety Res Unit, Fayetteville, AR 72701 USA

3.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Inst Agroprod Safety & Nutr, Hangzhou 310021, Peoples R China

关键词： antimicrobial resistance; antibiotic alternatives; antimicrobial peptides; host defense peptides; butyrate; forskolin; lactose; necrotic enteritis; coccidiosis; poultry

期刊名称：ANTIBIOTICS-BASEL （ 影响因子：4.639； 五年影响因子：4.849 ）

ISSN： 2079-6382

年卷期： 2021 年 10 卷 10 期

页码：

收录情况： SCI

摘要： The rising concern of antimicrobial resistance highlights a need for effective alternatives to antibiotics for livestock production. Butyrate, forskolin, and lactose are three natural products known to induce the synthesis of host defense peptides (HDP), which are a critical component of innate immunity. In this study, the synergy among butyrate, forskolin, and lactose in enhancing innate host defense, barrier function, and resistance to necrotic enteritis and coccidiosis was investigated. Our results indicated that the three compounds synergistically augmented the expressions of multiple HDP and barrier function genes in chicken HD11 macrophages. The compounds also showed an obvious synergy in promoting HDP gene expressions in chicken jejunal explants. Dietary supplementation of a combination of 1 g/kg sodium butyrate, 10 mg/kg forskolin-containing plant extract, and 10 g/kg lactose dramatically improved the survival of chickens from 39% to 94% (p < 0.001) in a co-infection model of necrotic enteritis. Furthermore, the three compounds largely reversed growth suppression, significantly alleviated intestinal lesions, and reduced colonization of Clostridium perfringens or Eimeria maxima in chickens with necrotic enteritis and coccidiosis (p < 0.01). Collectively, dietary supplementation of butyrate, forskolin, and lactose is a promising antibiotic alternative approach to disease control and prevention for poultry and possibly other livestock species.

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