文献类型： 外文期刊

作者： Liu, Qingpo ¹ ; Dou, Shijuan ² ; Wang, Guang'en ³ ; Li, Zhimin ⁴ ; Feng, Ying ⁵ ;

作者机构： 1.Zhejiang Forestry Univ, Sch Agr & Food Sci, Hangzhou 311300, Zhejiang, Peoples R China

2.Hebei Agr Univ, Coll Life Sci, Baoding 071000, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Cotton Inst, Shijiazhuang 050051, Peoples R China

4.Handan Polytech Coll, Dept Management, Handan 056002, Peoples R China

5.Zhejiang Univ, Coll Environm & Resources Sci, Hangzhou 310029, Zhejiang, Peoples R China

关键词： MCT;Transporter;Phylogeny;Functional divergence;Functional constraint;Vertebrate

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN： 0378-1119

年卷期： 2008 年 423 卷 1 期

页码：

收录情况： SCI

摘要： Monocarboxylate transporters (MCTs) form a gene family with an ancient past. The identification of MCTs (MCHs) from bacteria, protozoa, fungi, invertebrates, as well as vertebrates, but not from plants and virus, allowed illuminating the phylogenetic and evolutionary history of this gene family. The significant expansion of vertebrate MCT genes should have primarily occurred after the divergence of vertebrates and invertebrates, but before the divergence time between ray-finned fish and mammals. The divergence of insect MCTs should have at least occurred in the common ancestor of fruit fly, beetle, and honeybee. Fungi monocarboxylate transporter homologues (MCHs) might evolve independently from an ancient ancestor. The results of functional divergence analysis provided statistical evidences for shifted evolutionary rate and/or changes of amino acid property after gene duplication. The sliding window analysis of the d(N)/d(S) ratio values showed that strong functional constraints must impose on the N- and C-terminal domains of vertebrate MCTs. These corresponding regions may play crucial roles for functionality of MCT proteins. (C) 2008 Elsevier B.V. All rights reserved.