文献类型： 外文期刊
作者： Zhou, R. Y. 1 ; Li, X. L. 1 ; Li, L. H. 1 ; Wang, H. Y. 2 ; Lue, J. G. 3 ;
作者机构： 1.Agr Univ Hebei, Coll Anim Sci & Technol, Baoding 071001, Hebei, Peoples R China
2.Hebei Acad Agr & Forestry Sci, Anim Nutr Ctr, Inst Genet & Physiol, Shijiazhuang 050051, Peoples R China
3.Tangshan Anim Husbandry Workstn Hebei Province, Tangshan 063000, Peoples R China
期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）
ISSN： 0304-8608
年卷期： 2008 年 153 卷 5 期
页码：
收录情况： SCI
摘要： The polymorphism of the PRNP gene plays a key role in susceptibility to prion disease. Scrapie is a neurodegenerative disease affecting sheep and goats and belongs to the group of prion diseases. We isolated DNA from 333 goat samples representing the main local goat breeds in six provinces in China to identify PRNP polymorphisms and to determine whether these breeds were at risk for developing scrapie. Two novel amino acid polymorphisms (R211G and T219I) and a novel silent mutation at codon 125 as well as nine previously reported polymorphisms were observed. Twenty-eight alleles and forty-nine different genotypes were obtained. The codon 142M associated with resistance of goat scrapie was not found in this study. The codon 143R was relatively rare. The codon 222K, a potentially useful candidate site for selecting for scrapie resistance, was also rare in indigenous Chinese goats. These results could provide some useful data for assessing the risk of scrapie in Chinese indigenous goats.
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