Meta-analysis of the association between PADI4-92C/G polymorphism and rheumatoid arthritis in the Chinese population
文献类型： 外文期刊
作者： Guo, Z. Y. 1 ; Zhang, J. X. 3 ; Wu, M. 4 ; Mei, Y. F. 2 ; Lin, X. J. 1 ; Bu, C. 5 ; Xie, Y. 5 ; Wang, J. 5 ;
作者机构： 1.Zhejiang Univ, Dept Orthoped Surg, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
2.Sanmen People Hosp, Dept Orthoped Surg, Sanmen, Peoples R China
3.Lishui Acad, Dept Orthoped Surg, Qingtian People Hosp, Affiliated Hosp, Qingtian, Peoples R China
4.Sanmen People Hosp, Dept Combine Western Med & Tradit Chinese Med, Sanmen, Peoples R China
5.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, Hangzhou, Zhejiang, Peoples R China
关键词： Meta-analysis;Peptidylarginine deiminase 4;Polymorphism;Rheumatoid arthritis
期刊名称：BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH （ 影响因子：2.59； 五年影响因子：2.523 ）
ISSN： 0100-879X
年卷期： 2017 年 50 卷 10 期
页码：
收录情况： SCI
摘要： Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between PADI4 -92C/G polymorphism and RA. Eligible studies published before May 2016 were identified in PubMed and Chinese databases. The strengths of these associations were assessed by pooled odds ratios (OR) and 95% confidence interval (CI). Eight studies documenting a total of 1351 RA cases and 1585 controls were included in this meta-analysis. In the overall analysis, a significant association between the PADI4 -92C/G polymorphism and RA was found in the Chinese population (G vs C: OR=1.32, 95% CI=1.02-1.71; GG+ CG vs CC: OR=1.75, 95% CI=1.20-2.53). The subgroup analyses stratified by geographic area(s) and source of controls revealed significant results in South China, in hospital-based studies and population-based studies. In summary, this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the RA incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.
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