Glucagon-like peptide-2-loaded microspheres as treatment for ulcerative colitis in the murine model
文献类型： 外文期刊
作者： Wu, Jie 1 ; Qi, Keke 1 ; Xu, Ziwei 1 ; Wan, Jin 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China
关键词： DSS;microspheres;pGLP-2;PLGA;ulcerative colitis
期刊名称：JOURNAL OF MICROENCAPSULATION （ 影响因子：3.142； 五年影响因子：2.933 ）
ISSN： 0265-2048
年卷期： 2015 年 32 卷 6 期
页码：
收录情况： SCI
摘要： Glucagon-like peptide-2 (GLP-2) is an intestinal hormone that promotes intestinal growth, but the rapid degradation by dipeptidyl peptidase-IV limits its applications. PLGA microsphere is a well-developed drug delivery system, while seldom been studied as a solution for prolonging in vivo effects of GLP-2. In this study, we encapsulated porcine GLP-2 (pGLP-2) into microspheres and investigated its therapeutic effects in dextran sulfate sodium (DSS)-treated mice. pGLP-2 microspheres showed 20.36% in initial burst and constant release for at least 9 d. In the DSS-treated mice, a single injection of GLP-2 microspheres significantly increased the body weight, colonic length, small intestinal weight and mRNA expression of Occludin, decreased the colonic damage score, mRNA expression of IL-6, IL-10, TNF-alpha and IFN-gamma. In conclusion, pGLP-2 microspheres were resistant to degradation and decreased the severity of DSS-induced ulcerative colitis which suggested that GLP-2-loaded microspheres could be a proper candidate for the treatment of ulcerative colitis.
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