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Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer

文献类型: 外文期刊

作者: Zhu, Wang-Yu 2 ; Luo, Bin 2 ; An, Ji-yuan 3 ; He, Jian-ying 2 ; Chen, Dong-dong 2 ; Xu, Li-Yun 2 ; Huang, Yan-Yan 2 ; Liu 1 ;

作者机构: 1.Zhoushan Hosp, Dept Cardiothorac Surg, Zhoushan 316004, Zhejiang, Peoples R China

2.Zhoushan Hosp, Zhoushan Hosp BIG CAS, Dept Joint Lab Immunogen, Zhoushan 316004, Zhejiang, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Digital Agr, Hangzhou, Zhejiang, Peoples R China

关键词: miRNA;NSCLC;Early detection;Prognosis

期刊名称:CANCER INVESTIGATION ( 影响因子:2.176; 五年影响因子:2.344 )

ISSN: 0735-7907

年卷期: 2014 年 32 卷 8 期

页码:

收录情况: SCI

摘要: Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e andmiR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.

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