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Antioxidative and Hepatoprotective Activities of Deinoxanthin-Rich Extract from Deinococcus radiodurans R1 against Carbon Tetrachloride-Induced Liver Injury in Mice

文献类型： 外文期刊

作者： Cheng, Jianhui 1 ; Zhang, Zuofa 2 ; Zheng, Zhiguo 1 ; Lv, Guoying 2 ; Wang, Liangyan 1 ; Tian, Bing 1 ; Hua, Yuejin 1 ;

作者机构： 1.Zhejiang Univ, Inst Nucl Agr Sci, Hangzhou 310029, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Dept Hort, Hangzhou 310021, Zhejiang, Peoples R China

3.Zhejiang Canc Hosp, Canc Res Inst, Hangzhou 310020, Zhejiang, Peoples R China

关键词： Antioxidant;Deinoxanthin;Deinococcus radiodurans;Hepatoprotective;Carbon tetrachloride;Liver damage

期刊名称：TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH （ 影响因子：0.533； 五年影响因子：0.743 ）

ISSN： 1596-5996

年卷期： 2014 年 13 卷 4 期

页码：

收录情况： SCI

摘要： Purpose: To investigate the antioxidant activity and hepatoprotective effect of deinoxanthin-rich extract from Deinococcus radiodurans (EDR) against CCl4-induced liver injury in mice. Methods: The ethanol extract of EDR was analyzed by liquid chromatography/mass spectrometry (LC/MS), and its antioxidant activity was examined using in vitro assays for reducing power, iron chelating activity and lipid peroxidation. The extract was also evaluated for its hepatoprotective activity against carbon tetrachloride-induced liver injury in mice. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) in serum, and catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver tissue, as well as hepatic malondialdehyde (MDA) levels, were measured to monitor liver injury. Damage to liver cells was assessed by histology. Results: EDR displayed strong reducing activity and lipid peroxidation inhibition activity in vitro. Pretreatment with EDR (400 mg/kg b.w.) significantly reduced activities of serum ALT, AST and ALP, as well as hepatic MDA levels (p < 0.05), but increased the activities of GSH-Px, CAT and SOD. Histopathological assessment showed that liver tissue damage was decreased by the protective effect of EDR. Conclusion: The results show that EDR can protect mice against CCl4-induced hepatic damage by its antioxidant and free radical scavenging activities.

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