DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related
文献类型： 外文期刊
作者： Lu, Na 1 ; Hu, Yongfei 1 ; Zhu, Liying 3 ; Yang, Xi 1 ; Yin, Yeshi 4 ; Lei, Fang; Zhu, Yongliang; Du, Qin; Wang, Xi 1 ;
作者机构： 1.Chinese Acad Sci, Inst Microbiol, CAS key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Beijing Key Lab Microbial Drug Resistance & Resi, Beijing, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Zhejiang, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Zhejiang, Peoples R
期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）
ISSN： 2045-2322
年卷期： 2014 年 4 卷
页码：
收录情况： SCI
摘要： The human gut is a reservoir for antibiotic resistance genes. In this report, we used a DNA microarray chip covering 369 resistance types to investigate the relationship between antibiotic resistance-gene diversity and human age. Metagenomic DNA from fecal samples from 124 healthy volunteers of four different age groups (pre-school-aged children (CH), school-aged children (SC), high school students (HSS) and adults (AD)) were hybridized to the microarray chip. The results showed that 80 different gene types were recovered from the gut microbiota of the 124 individuals: 25 from CH, 37 from SC, 58 from HSS and 72 from AD. Further analysis indicated that the antibiotic resistance genes in the CH, SC and AD groups clustered independently, whereas the gene types in the HSS group were more divergent. Our results indicated that antibiotic resistance genes in the human gut microbiota accumulate from childhood to adulthood and become more complex with age.
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