Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells
文献类型： 外文期刊
作者： Zhang, H. 1 ; Chen, F. 1 ; Li, G. L. 3 ; Ding, Y. Y. 3 ; Tao, Z. R. 1 ; Li, J. J. 1 ; Zhong, S. L. 4 ; Lu, L. Z. 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou, Zhejiang, Peoples R China
2.Nanjing Agr Univ, Coll Anim Sci, Nanjing, Jiangsu, Peoples R China
3.Ping Yang Sci & Technol Bur, Wenzhou, Zhejiang, Peoples R China
4.PingYang XingLiang Pigeon Farming Co Ltd, Wenzhou, Zhejiang, Peoples R China
关键词： Estrogen receptor;Estrogen expression;siRNA;Estrogen regulation;Oviduct epithelial cells
期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）
ISSN： 1676-5680
年卷期： 2014 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Estrogen regulates reproductive behavior and drives the proliferation and differentiation of several cell types. These physiological functions of estrogen are mediated by estrogen receptors (ERs), and each ER isoform plays a distinct role. To clarify the molecular mechanism of estrogen action and to evaluate the effect of ERs on the secretion of ovalbumin (OVA) in pigeon oviduct epithelial cells (POECs), we determined the complete coding sequences encoding ER alpha (ER alpha) and ER beta (ER beta) in pigeons. The abundance of pigeon ER alpha and ER beta mRNA was detected using quantitative polymerase chain reaction. These results revealed that pigeon ER alpha is highly expressed in the oviduct, while pigeon ER beta is highly expressed in the ovary and kidney. We hypothesize that ERa mRNA predominates over that of ER beta in the oviduct. The expression of ER alpha can be down-regulated by 17 beta-estradiol, and the knockdown of ER alpha promoted OVA mRNA expression in cultured POECs, indicating that ERa may play an important role in OVA secretion.
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