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Induction of specific immune responses in piglets by intramuscular immunization with fimbrial adhesin FaeG expressed in Lactococcus lactis

文献类型： 外文期刊

作者： Liu, Shujie 1 ; Li, Yongming 1 ; Xu, Ziwei 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Enterotoxigenic Escherichia coli;FaeG;Lactococcus lactis;Immune response;Vaccine

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

ISSN： 0034-5288

年卷期： 2013 年 95 卷 1 期

页码：

收录情况： SCI

摘要： Fimbrial adhesin plays a critical role in the pathogenesis of enterotoxigenic Escherichia coli (ETEC)-induced piglet diarrhoea. Lactococcus lactis is an attractive food-grade host for the production of heterologous antigens. We previously demonstrated that fimbrial adhesin FaeG was expressed in L lactis and that oral immunization in mice with recombinant L lactis expressing FaeG induced F4-specific mucosal and systemic immune responses. In the present study, we explored the immune responses of piglets induced by intramuscular vaccination with recombinant L. lactis expressing rFaeG. Intramuscular vaccination resulted in significantly elevated serum IgG level and modest increases in serum IgA and IgM levels. In addition, IgG, IgA, and IgM antibody secreting cells were induced in the spleen, mesenteric lymph nodes, and jejunum. The growth performance of piglets was not influenced by intramuscular vaccination. The results suggest that L. lactis expressing FaeG is a promising candidate vaccine against ETEC. (c) 2013 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]Subcutaneous or Oral Immunization of Mice with Lactococcus lactis Expressing F4 Fimbrial Adhesin FaeG. Liu, Shujie,Li, Yongming,Xu, Ziwei,Wang, Yicheng. 2013

[2]Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes. Li, GJ,Chen, WZ,Yan, WY,Zhao, K,Liu, MQ,Zhang, J,Fei, L,Xu, QX,Sheng, ZT,Lu, YG,Zheng, ZX.

[3]产肠毒素大肠杆菌K88黏附素蛋白亚基Fae G在L.lactis中的表达及其抗原性. 刘淑杰,李永明,徐子伟,王一成. 2009

[4]Recombinant Lactococcus lactis expressing porcine insulin-like growth factor I ameliorates DSS-induced colitis in mice. Liu, Shujie,Li, Yongming,Deng, Bo,Xu, Ziwei. 2016

[5]Enhancement of immune responses to Newcastle disease vaccine by a supplement of extract of Momordica cochinchinensis (Lour.) Spreng. seeds. Xiao, C.,Hu, S.,Xiao, C.,Bao, G.. 2009

[6]Short communication. Enhancement of the immune responses to vaccination against foot-and-mouth disease in mice by oral administration of Quillaja saponaria-A and extracts of Cochinchina momordica seed. Xiao, C. W.,Bao, G.,Rajput, Z. I.,Hu, S. H.,Rajput, Z. I.,Soomro, N. A.. 2013

[7]Expression of an immunologically (MSP-1(42)) reactive merozoite surface protein in E-coli. Leung, WH,Meng, ZQ,Hui, G,Ho, WK.

[8]Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunization. Liu, Shujie,Li, Yongming,Xu, Ziwei,Wang, Yicheng,Liu, Shujie,Xu, Ziwei.

[9]Greater efficacy of the ECMS-oil adjuvant over other formulations on immune responses against Bordetella bronchiseptica in rabbits and the underlying mechanism. Xiao, Chenwen,Bao, Guolian,Liu, Yan,Wei, Qiang,Ji, Quanan,Liu, Yaping,Pan, Lijun.

[10]Enhancement of immune responses to infectious bursal disease vaccine by supplement of an extract made from Momordica cochinchinensis (Lour.) Spreng. seeds. Rajput, Z. I.,Xiao, C. W.,Hu, S. H.,Rajput, Z. I.,Xiao, C. W.,Habib, M.,Soomro, N. A..

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