文献类型： 外文期刊

作者： Wang Zhan-li ² ; Zhang Sai-sai ¹ ; Wang Wei ³ ; Feng Feng-qin ¹ ; Shan Wei-guang ² ;

作者机构： 1.Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou 310029, Zhejiang, Peoples R China

2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Qual & Stand Agr Prod, Hangzhou 310021, Zhejiang, Peoples R China

关键词： novel angiotensin I converting enzyme;inhibitory peptide;virtual screening;docking

期刊名称：AGRICULTURAL SCIENCES IN CHINA （ 影响因子：0.82； 五年影响因子：0.997 ）

ISSN： 1671-2927

年卷期： 2011 年 10 卷 3 期

页码：

收录情况： SCI

摘要： Angiotensin I converting enzyme (ACE) plays an important physiological role in the regulation of hypertension. In this study, we applied virtual screening to discover a novel angiotensin I converting enzyme inhibitory peptides from milk casein. One potential hit was identified based on docking scores, subsequently confirmed by activity studies in vitro (IC(50)=20.85 mu mol L(-1)). The proposed peptide in this study contains a unique sequence, Lys-Val-Leu-Ile-Leu-Ala. Moreover, we performed the docking studies to understand the binding mode between the enzyme and peptide hit.