文献类型： 外文期刊

作者： Zhu, L. H. ² ; Li, C. ¹ ; Wu, J. A. ² ; Liang, J. G. ² ; Shi, Y. F. ² ;

作者机构： 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 10083, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Zhejiang, Peoples R China

期刊名称：TRANSPLANTATION PROCEEDINGS （ 影响因子：1.066； 五年影响因子：1.085 ）

ISSN： 0041-1345

年卷期： 2008 年 40 卷 10 期

页码：

收录情况： SCI

摘要： Chronic allograft dysfunction is the primary cause of graft loss after the first posttransplantation year. Bacteriocins are biologically active proteins exhibiting antimicrobial properties against other bacterial species, which are usually closely related to the producer organism. The objective of our study was to determine whether lactic acid bacterial bacteriocins were associated with tumor necrosis factor (TNF)-alpha observed in a rat kidney model of chronic rejection. Using a kidney model of chronic rejection in the rat, we administered cyclosporine (CsA) inummosuppression (5 mg/kg/d). One group of animals was treated with bacteriocins, and the other was left untreated. Grafts were harvested after transplantation for standard histological studies. The expression of TNF-alpha was demonstrated using immunohistochemistry of frozen sections of the grafts. We observed a greater increase in the expression of TNF-alpha among the group treated with bacteriocins compared with the untreated group. These results showed that lactic acid bacterial bacteriocins were associated with TNF-alpha in our kidney graft model.