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Preparation and evaluation of chitosan/alginate porous microspheres/Bletilla striata polysaccharide composite hemostatic sponges

文献类型： 外文期刊

作者： Wang, Chao 1 ; Luo, Wenfeng 1 ; Li, Puwang 2 ; Li, Sidong 3 ; Yang, Ziming 2 ; Hu, Zhang 3 ; Liu, Yangyang 2 ; Ao, Ningji 1 ;

作者机构： 1.Jinan Univ, Inst Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China

2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

3.Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China

关键词： Chitosan;Alginate-calcium;Bletilla striata polysaccharide;Microspheres;Hemostatic sponge

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2017 年 174 卷

页码：

收录情况： SCI

摘要： We prepared a novel hemostatic material using chitosan (CS), alginate, and Bletilla striata, which showed good biocompatibility and hemostatic properties. Alginate-calcium porous microspheres (Alg) were prepared by emulsification/cross-linking methods, and Bletilla striata polysaccharide (Bsp) was extracted from the tubers by water extraction and alcohol precipitation. To improve the water absorption and accelerate the blood coagulation, Alg and Bsp were mixed with chitosan solution to form CS/Alg and CS/Alg/Bsp composite sponges by lyophilization. Based on SEM images, the microspheres exhibited good spherical shape, possessed many pores on the surface, and were well dispersed in the CS/Alg5 and CS/Alg10 composite sponges. The CS/Alg10 composite sponges showed higher water absorption and porosity. In addition, the cytotoxicity assay and hemostatic property of the CS/Alg and CS/Alg/Bsp composite sponges were tested by CCK-8 assay, in vitro blood clotting, red blood cell (RBC) adhesion, and rabbit ear artery bleeding. These ternary composite sponges could be used as potential novel hemostatic materials in surgical treatment. (C) 2017 Elsevier Ltd. All rights reserved.

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